Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

USP12 Facilitates Gastric Cancer Progression via Stabilizing YAP

April 12, 2024

[Cell Death Discovery] The authors conducted a screening using a deubiquitinase small interfering RNA library, leading to the identification of USP12 as an important deubiquitinase in the context of Hippo/YAP axis and the progression of gastric cancer.

LPCAT2 Inhibits Colorectal Cancer Progression via the PRMT1/SLC7A11 Axis

April 12, 2024

[Oncogene] Scientists identified LPCAT2+ tumor cell populations with less malignancy than LPCAT2- tumor cells in human and mouse colorectal cancer (CRC) tissues using scRNA-seq. Combining in vitro and in vivo experiments, they found that LPCAT2 could inhibit the proliferation of CRC cells by inducing ferroptosis.

The Phosphatase Inhibitor LB-100 Creates Neoantigens in Colon Cancer Cells Through Perturbation of mRNA Splicing

April 11, 2024

[EMBO Reports] Scientists reported a sensitivity of the mRNA splicing machinery to phosphorylation changes in response to LB-100 in colorectal adenocarcinoma.

Colonic Crypt Stem Cell Functions Are Controlled by Tight Junction Protein Claudin-7 Through Notch/Hippo Signaling

April 11, 2024

[Annals Of The New York Academy Of Sciences] Scientists explored the role of claudin-7 in regulating colonic intestinal stem cell function. In 3D colonoid culture, claudin-7–deficient crypts were unable to survive and form spheroids. Inhibition of the Hippo pathway or activation of Notch signaling partially rescued the defective stem cell behavior.

The Role of Goblet Cells in Crohn’s Disease

April 10, 2024

[Cell And Bioscience] Scientists introduce the disease-related functions of goblet cells, their relationship with Crohn's disease, their possible mechanisms, and current Crohn's disease treatments targeting goblet cells.

DHX9 Maintains Epithelial Homeostasis by Restraining R-Loop-Mediated Genomic Instability in Intestinal Stem Cells

April 10, 2024

[Nature Communications] The authors observed reduced DEAH-box helicase 9 (DHX9) protein levels in IBD patients, and mice with conditional DHX9 depletion in the intestinal epithelium exhibited an increased susceptibility to experimental colitis.

Combination of Bazedoxifene with Chemotherapy and SMAC-Mimetics for the Treatment of Colorectal Cancer

April 10, 2024

[Cell Death & Disease] Investigators reported that bazedoxifene inhibited tumor growth via direct interaction with the gp130 receptor to suppress interleukin-6 (IL-6) and IL-11-mediated signal transducer and activator of transcription 3 signaling.

Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target

April 8, 2024

[Gastroenterology] Using a Muc6 knockout mouse model, gastric organoids, and cell lines, the authors proposed that Golgi stress responses and aberrant glycans induced by mucin deletion were important drivers of gastric cancer.

POLQ Inhibition Attenuates the Stemness and Ferroptosis Resistance in Gastric Cancer Cells via Downregulation of Dihydroorotate Dehydrogenase

April 8, 2024

[Cell Death & Disease] The authors reported that polymerase theta (POLQ), a widely conserved DNA polymerase, positively regulated stem cell-like characteristics of gastric cancer (GC) cells. Knockdown of POLQ suppressed the stemness of GC cells in vitro and in vivo.

Eunyoung Choi’s Gastric Cancer Research Merits AACR-Debbie’s Dream Funding

April 8, 2024

[Vanderbilt University Medical Center] Dr. Eunyoung Choi is one of three inaugural recipients of an American Association for Cancer Research (AACR)-Debbie’s Dream Foundation Innovation and Discovery Grant. Supported by the $50,000 grant, Dr. Choi and her research team seek to evaluate the potential of aberrant fatty acid metabolism as a novel druggable target for prevention or treatment of gastric cancer.

p53 Promotes Revival Stem Cells in the Regenerating Intestine after Severe Radiation Injury

April 8, 2024

[Nature Communications] Scientists performed single-cell RNA-seq and lineage tracing experiments and demonstrated that transient activation of p53 was required to properly reprogram damaged epithelial cells in response to severe radiation injury to promote tissue regeneration.

Varley Awarded Research Grant From the American Cancer Society and UW Carbone Cancer Center

April 4, 2024

[University of Wisconsin-Madison] Dr. Patrick Varley was awarded a one-year, $60,000 Institutional Research Grant that is jointly funded by the American Cancer Society and the University of Wisconsin (UW) Carbone Cancer Center. The award provides funding for a pilot study evaluating the effect of residential neighborhood disparities on colorectal cancer outcomes within the Veterans Health Administration system.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.