Volume 2.14 | Apr 22

Intestinal Cell News 2.14 April 22, 2016
Intestinal Cell News
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Misregulation of DNA Building Blocks Associated with the Development of Colon Cancer
Researchers found that the protein SAMHD1, which is involved in the break-down of dNTP, is often mutated in colon cancer cells. Further studies in mice, yeast, and cultures of human cells showed that these cancer-specific mutations eliminated the SAMHD1 function and that this led to an elevation and imbalance in dNTP levels and hence an increased mutation rate. [Press release from Umeå University discussing online prepublication in Proceedings of the National Academy of Sciences]
Press Release | Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer
The authors examined the requirement of L-fucose in colorectal cancer (CRC) cells and developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specific to CRC. [J Natl Cancer Inst] Abstract

Gastric Lgr5+ Stem Cells Are the Cellular Origin of Invasive Intestinal-Type Gastric Cancer in Mice
Researchers deleted Smad4 and PTEN in murine gastric Lgr5+ stem cells by the inducible Cre-LoxP system and marked mutant Lgr5+ stem cells and their progeny with Cre-reporter Rosa26tdTomato. [Cell Res] Full Article

Neonatal Colonization of Mice with LGG Promotes Intestinal Development and Decreases Susceptibility to Colitis in Adulthood
Scientists developed an approach to colonize conventionally raised mice with a model probiotic bacterium, Lactobacillus rhamnosus GG (LGG), and to determine the effects of LGG colonization on intestinal development and prevention of colitis in adulthood. [Mucosal Immunol] Abstract

Ablating the Aryl Hydrocarbon Receptor (AhR) in CD11c+ Cells Perturbs Intestinal Epithelium Development and Intestinal Immunity
Investigators report that Cre-mediated deletion of AhR in CD11c-expressing cells in C57/BL6 mice is associated with altered intestinal epithelial morphogenesis in vivo. [Sci Rep] Full Article

Curcumin Mediates Oxaliplatin-Acquired Resistance Reversion in Colorectal Cancer Cell Lines through Modulation of CXC-Chemokine/NF-κB Signaling Pathway
The authors showed that NF-κB was hyperactivated in in vitro models of oxaliplatin-acquired resistance but was attenuated by the addition of Curcumin, a non-toxic NF-κB inhibitor. [Sci Rep] Full Article

Posttranscriptional Regulation of Wnt-Coreceptor LRP6 and RNA-Binding Protein HuR by miR-29b in Intestinal Epithelial Cells
Researchers report that mRNAs, encoding Wnt coreceptor LRP6 (LDL receptor-related protein 6) and RNA-binding protein HuR, are novel targets of microRNA-29b (miR-29b) in intestinal epithelial cells and that expression of LRP6 and HuR is tightly regulated by miR-29b at the posttranscriptional level. [Biochem J] Abstract

MicroRNA-204 Modulates Colorectal Cancer Cell Sensitivity in Response to 5-Fluorouracil-Based Treatment by Targeting High Mobility Group Protein A2
Investigators identified high mobility group protein A2 (HMGA2) as a novel direct target of miR-204 and showed that miR-204 expression was decreased while HMGA2 expression was increased in colorectal cancer cell lines. [Biol Open] Full Article


In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment
Colonic organoids derived from cultured, multicellular organoid fragments or single stem cells were exposed in culture to steep linear gradients of two Wnt-signaling ligands, Wnt-3a and R-spondin1. [PLoS One] Full Article

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Mucosal Pathobiology and Molecular Signature of Epithelial Barrier Dysfunction in the Small Intestine in Irritable Bowel Syndrome
The authors summarize the most recent findings on mucosal barrier alterations and its relationship to symptoms arising from the small intestine in irritable bowel syndrome (IBS), including epithelial structural abnormalities, mucosal immune activation, and microbial dysbiosis, further supporting the hypothesis of an organic origin of IBS. [J Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Ludwig’s Luis Diaz to Deliver Plenary at 2016 AACR Annual Meeting on Liquid Biopsies for the Early Detection of Cancer
Ludwig Cancer Research scientist Luis Diaz gave a plenary lecture. His talk, titled “Liquid Biopsies and the Early Diagnosis of Cancer,” will survey the scientific history and current state of efforts to develop minimally invasive diagnostic tests for the early detection of cancer. [Press release from Ludwig Cancer Research discussing research presented at the Annual Meeting of the American Association for Cancer Research (AACR), New Orleans.] Press Release

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Synergy Pharmaceuticals Announces Acceptance of New Drug Application for Plecanatide, a Novel Uroguanylin Analog, in Chronic Idiopathic Constipation
Synergy Pharmaceuticals Inc. announced the U.S. Food and Drug Administration has determined that the company’s new drug application for plecanatide, its first uroguanylin analog, for the treatment of chronic idiopathic constipation is sufficiently complete to permit a substantive review. [Synergy Pharmaceuticals Inc.] Press Release

AbbVie, University of Chicago Collaborate to Advance Cancer Research
The University of Chicago and AbbVie have entered into a five-year collaboration agreement designed to improve the pace of discovery and advance medical research in oncology at both organizations. [The University of Chicago] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Summit for Cancer Immunotherapy
June 26-29, 2016
Halifax, Canada

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Research Assistant – Autoimmune/Cell Biology (Immunocore Ltd)

NEW Clinical Fellow – Cancer Immunotherapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Scientist – Inflammation (University of Oxford)

Associate or Senior Editor – Epigenetics (Springer Nature)

Faculty Positions – Clinical Immunology (Oklahoma Medical Research Foundation )

Grant Writer (Gladstone Institutes)

PhD Studentship – Pectin in Human Intestinal Tract (Wageningen University)

PhD Studentship – Transcriptional Regulation in Colon Cancer (University of Helsinki)

Postdoctoral Scientist – Inflammation (University of Oxford)

Postdoctoral Fellow – Nanomedicine (Johns Hopkins University)

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