Volume 2.08 | Mar 4

Intestinal Cell News 2.08 March 4, 2016
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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High-Fat Diet Linked to Intestinal Stem Cell Changes, Increased Risk for Cancer
Scientists revealed how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous. The study of mice suggested that a high-fat diet drives a population boom of intestinal stem cells and also generates a pool of other cells that behave like stem cells — that is, they can reproduce themselves indefinitely and differentiate into other cell types. [Press release from Massachusetts Institute of Technology discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells
The authors assessed the significance of prolyl hydroxylase (PHD) enzymes during the metastatic spread of colorectal cancer. PHD expression analysis in 124 colorectal cancer patients revealed that reduced tumoral expression of PHD3 correlated with increased frequency of distant metastases and poor outcome. [Cancer Res] Abstract

MACC1 Mediates Acetylcholine-Induced Invasion and Migration by Human Gastric Cancer Cells
Researchers demonstrated that acetylcholine acts via M3 muscarinic receptor to promote gastric cancer cell invasion and migration as well as expression of several markers of epithelial-mesenchymal transition. [Oncotarget] Full Article

Thymic Stromal Lymphopoietin (TSLP) Inhibits Human Colon Tumor Growth by Promoting Apoptosis of Tumor Cells
Investigators found significantly decreased TSLP levels in tumor tissues compared with tumor-surrounding tissues of patients with colon cancer and TSLP levels negatively correlated with the clinical staging score of colon cancer. [Oncotarget] Full Article

Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix
Researchers investigated the biochemical and physical diversity of extracellular matrix in pair-wised comparisons of healthy, perilesional and colorectal carcinoma specimens. [Sci Rep] Full Article

PS341 Inhibits Hepatocellular and Colorectal Cancer Cells through the FOXO3/CTNNB1 Signaling Pathway
Scientists demonstrated that PS341 negatively regulated hepatocellular carcinoma and colorectal cancer both in vitro and in vivo, including the inhibition of cell proliferation, epithelial-mesenchymal transition, the expression of stemness-related genes, cell migration and invasiveness. [Sci Rep] Full Article

Targeted CFTR Gene Disruption with Zinc-Finger Nucleases in Human Intestinal Epithelial Cells Induces Oxidative Stress and Inflammation
Intestinal Caco-2/15 cells with CFTR deletion, displayed innate oxidative and inflammatory features while being more sensitive to pro-oxidant and pro-inflammatory stimuli. [Int J Biochem Cell Biol] Abstract


Stem Cell-Specific Endocytic Degradation Defects Lead to Intestinal Dysplasia in Drosophila
Researchers showed that UVRAG deficiency in Drosophila intestinal stem cells leads to uncontrolled proliferation and impaired differentiation without preventing autophagy. [Dis Model Mech] Abstract | Full Article

Cyclophilin A Is a New M Cell Marker of Bovine Intestinal Epithelium
Investigators developed a 2H5-F3 monoclonal antibody through its binding to bovine M cells, and identified the antibody reactive molecule as cyclophilin A. [Cell Tissue Res] Abstract

A Novel Culture System for Adult Porcine Intestinal Crypts
Jejunal crypts were isolated from murine, human, and juvenile and adult porcine small intestine, suspended in Matrigel, and co-cultured with syngeneic intestinal subepithelial myofibroblasts or cultured without feeder cells in various culture media. [Cell Tissue Res] Abstract

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Organoids as an In Vitro Model of Human Development and Disease
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. The authors discuss the current achievements, challenges and potential applications of this technique. [Nat Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
FDA Approves New Indication for Novartis Drug Afinitor® for Progressive, Nonfunctional GI and Lung Neuroendocrine Tumors (NET)
Novartis announced that the United States Food and Drug Administration (FDA) approved Afinitor® tablets for the treatment of adult patients with progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin that are unresectable, locally advanced or metastatic. [Novartis] Press Release

La Jolla Institute Receives $5 Million Gift from Pfizer
La Jolla Institute for Allergy and Immunology has received a $5 million gift, which will help establish the Mission Support for Cancer Immunology and Oncology Research. The Institute will use the majority of the funds to establish the Pfizer Endowed Chair in Cancer Immunology and Oncology and support research on the immune system and oncology. [La Jolla Institute for Allergy and Immunology] Press Release

Juno Therapeutics, Seattle Cancer Care Alliance and Fred Hutchinson Cancer Research Center Announce New Immuno-Oncology Clinical Trials Unit
Juno Therapeutics, Inc. and Fred Hutchinson Cancer Research Center announced the creation of a new, best-in-class clinical trials unit dedicated to immuno-oncology. [Juno Therapeutics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Gordon Research Conference – Tissue Niches & Resident Stem Cells in Adult Epithelia
August 7-12, 2016
Hong Kong, China

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Researcher – Mechanisms of Intestinal Persistence (Institute of Food Research)

NEW Program Director – IBD and Crohn’s Disease Program (The Leona M. and Harry B. Helmsley Charitable Trust)

NEW Faculty Position – Cancer Research (Texas Tech University)

NEW Postdoctoral Fellow – Nanomedicine (Johns Hopkins University)

Faculty Position – Cancer Research (Texas Tech University Health Sciences Center)

Postdoctoral Fellowship – Inflammatory Bowel Disease (Linköping University)

Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

Gastroenterologist – Inflammatory Bowel Disease (Mayo Clinic)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

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