Volume 2.03 | Jan 29

Intestinal Cell News 2.03 January 29, 2016
Intestinal Cell News
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Raf Kinase Inhibitor Protein Mediates Intestinal Epithelial Cell Apoptosis and Promotes IBDs in Humans and Mice
Researchers sought to identify the roles of Raf kinase inhibitor protein (RKIP) in maintaining homeostasis of the GI tract. RKIP contributed to colitis development by promoting inflammation and mediating intestinal epithelial cells apoptosis. [Gut] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Adenomatous Polyposis Coli (APC) Regulates miR17-92 Cluster through β-Catenin Pathway in Colorectal Cancer
Investigators revealed that miR-17-92 cluster is directly regulated by APC/β-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/β-catenin signaling. [Oncogene] Abstract

Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis through Transcriptional Repression of Interleukin-10
Scientists demonstrated a novel epigenetic mechanism of IL-10 dysregulation in inflammatory bowel disease. Down-regulation of lysine acetyltransferase 2B may disrupt the innate and adaptive inflammatory responses due to the suppression of this crucial anti-inflammatory cytokine. [J Crohns Colitis] Abstract

Stearoyl-CoA Desaturase-1 Mediated Cell Apoptosis in Colorectal Cancer by Promoting Ceramide Synthesis
In vitro study in colorectal cancer cells demonstrated inhibition of stearoyl-CoA desaturase 1 activity promoted apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species, alteration of mitochondrial transmembrane potential and translocation of mitochondrial protein cytochrome C. [Sci Rep] Full Article

Downregulation of CDC27 Inhibits the Proliferation of Colorectal Cancer Cells via the Accumulation of p21Cip1/Waf1
Investigators explored the biological and clinical significance of cell division cycle 27 (CDC27) in colorectal cancer growth and progression and investigated the underlying molecular mechanisms. [Cell Death Dis] Full Article

Long Non-Coding RNA AK027294 Involves in the Process of Proliferation, Migration, and Apoptosis of Colorectal Cancer Cells
Scientists investigated the differentially expressed long non-coding RNAs in colorectal cancer and its potential biological function. [Tumor Biol] Abstract | Full Article

Characterization of HAF-4- and HAF-9-Localizing Organelles as Distinct Organelles in Caenorhabditis elegans Intestinal Cells
The authors characterized a subset of the intestinal granules in which HAF-4 and HAF-9 localize on the membrane. HAF-4 and HAF-9 are ATP-binding cassette transporter proteins that are homologous to the mammalian lysosomal peptide transporter associated with antigen processing-like, ABCB9. [BMC Cell Biol] Full Article


Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis
Scientists showed that Survivin is specifically expressed in transit-amplifying cells and Lgr5+ stem cells. Genetic loss of Survivin in intestinal epithelial cells resulted in destruction of intestinal integrity, mucosal inflammation, and death of the animals. [Cell Rep] Full Article | Graphical Abstract

Co-Culture with Intestinal Epithelial Organoids Allows Efficient Expansion and Motility Analysis of Intraepithelial Lymphocytes
Researchers aimed at developing a novel co-culture system of intraepithelial lymphocytes with intestinal epithelial cells to investigate dynamic interaction between these two populations of cells in vitro. [J Gastroenterol] Abstract

Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids
Human intestinal crypts containing intestinal stem cells were cultured and differentiated into an epithelial layer with functional M cells with characteristic morphological and functional properties. [PLoS One] Full Article

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Blood-Based Biomarkers for Diagnosis, Prognosis and Treatment of Colorectal Cancer
The authors summarize the biomarkers currently thought to have potential for the early detection and monitoring of colorectal cancer, including circulating tumor cells, DNA, RNA and proteins. [Clin Chim Acta] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Data for KEYTRUDA® (Pembrolizumab) in a Range of Gastrointestinal Cancers to be Presented
Merck announced that new and updated findings investigating the use of KEYTRUDA® (pembrolizumab), the company’s anti-PD-1 therapy, in multiple gastrointestinal cancers will be presented. [Press release from Merck & Co., Inc. discussing research presented at the 2016 Gastrointestinal Cancers Symposium, San Francisco] Press Release

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UH Cancer Center Researcher Awarded $100,000 for Gastrointestinal Cancer Study
The Masami Horio Memorial Fund has awarded $100,000 to Scott Kuwada, MD, a professor in the Clinical and Translational Research Program at the University of Hawai‘i Cancer Center for his gastrointestinal cancer pilot study. [University of Hawaiʻi] Press Release

Vectibix® (panitumumab) and Best Supportive Care Improves Overall Survival Compared to Best Supportive Care in Chemorefractory KRAS And RAS Wild-Type Metastatic Colorectal Cancer
Amgen announced the presentation of detailed results of a Phase III study with Vectibix® and best supportive care (BSC) compared to BSC alone. [Amgen Inc.] Press Release

BioLineRx Receives Confirmation of Medical Device Classification in Europe for Celiac Treatment
BioLineRx Ltd. announced that it has received confirmation from the European Notified Body regarding the classification of BL-7010, a novel polymer for the treatment of celiac disease, as a Class IIb medical device in the European Union. [BioLineRx Ltd. (PR Newswire Association LLC.)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

Postdoctoral Research Scientist – Cancer Gene Research (University of Oxford)

Faculty Position – Gastrointestinal Physiology (University of Ottawa)

Postdoctoral Fellow – Cancer Genomics (Wellcome Trust Sanger Institute)

PhD Studentship – Cell Biology (Cologne Graduate School of Ageing Research)

Stem Cell Production Scientist (Definigen Ltd)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Postdoctoral Researcher – Host-Microbial Interactions (University of Oxford)

Postdoctoral Position – Gut Inflammation and IBD (University College Cork)

Postdoctoral Fellow – Cancer Immunotherapy (Inserm)

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