Volume 1.33 | Nov 6

Intestinal Cell News 1.33 November 6, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity
Researchers showed that polycomb repressive complex 1 (PRC1) activity is required for the integrity of the intestinal epithelium, regulating stem cell self-renewal via a cell-autonomous mechanism that is independent from Cdkn2a expression. [Cell Stem Cell] Abstract | Graphical Abstract
Free wallchart: The Intestinal Crypt
PUBLICATIONS (Ranked by impact factor of the journal)

The MAP3K ZAK, a Novel Modulator of ERK-Dependent Migration, Is Upregulated in Colorectal Cancer
Scientists showed that both isoforms of ZAK, ZAK-α and ZAK-β are key factors in cancer cell migration. [Oncogene] Abstract

Inhibition of Caspases Primes Colon Cancer Cells for 5-Fluorouracil-Induced TNF-α-Dependent Necroptosis Driven by RIP1 Kinase and NF-κB
Investigators explored the usage of pan-caspase inhibitors to sensitize resistant colorectal cancer cells for 5-fluorouracil. [Oncogene] Abstract

Epithelial IL-1R2 Acts as a Homeostatic Regulator during Remission of Ulcerative Colitis
Researchers aimed to identify the endogenous regulatory mechanisms that may promote disease remission. [Mucosal Immunol] Full Article

N-Glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and CDX1/Villin mRNA Expression
Investigators characterized the N-glycan profiles of 25 different colorectal cancer cell lines, derived from primary tumors and metastatic sites, in order to investigate their potential as glycobiological tumor model systems, and to reveal glycans associated with cell line phenotypes. [Mol Cell Proteomics] Abstract | Full Article

H2S, a Novel Gasotransmitter, Involved in Gastric Accommodation
Researchers investigated the role of H2S in gastric accommodation using CBS+/− mice, immunohistochemistry, immunoblot, methylene blue assay, intragastric pressure recording and electrical field stimulation. [Sci Rep] Full Article

IL-10-Producing CD4+ T Cells Negatively Regulate Fucosylation of Epithelial Cells in the Gut
Scientists showed that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. [Sci Rep] Full Article

Isolation of Human Colon Stem Cells Using Surface Expression of PTK7
Investigators identified stem cell markers that would allow for purification of human colonic stem cells. [Stem Cell Reports] Full Article

Unmethylated CpG Motifs in Toxoplasma gondii DNA Induce TLR9- and IFN-β-Dependent Expression of α-Defensin-5 in Intestinal Epithelial Cells
The authors showed that α-defensin-5 is rapidly upregulated in intestinal epithelial cells following intracellular Toll-like receptor 9 (TLR9) activation by unmethylated CpG motifs in DNA from T. gondii. [Parasitology] Abstract


Radiation-Induced Hyperproliferation of Intestinal Crypts Results in Elevated Genome Instability with Inactive p53-Related Genomic Surveillance
The authors determined the genomic surveillance process during crypt hyperproliferation, and its consequential outcome after ionizing radiation. [Life Sci] Abstract

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Nanomedicine and Drug Delivery Strategies for Treatment of Inflammatory Bowel Disease
The authors review nanomedicine treatments, such as the use of small interfering RNAs, antisense oligonucleotides, and anti-inflammatory molecules with delivery systems in experimental colitis models and clinical trials for inflammatory bowel disease based on a systematic search. [World J Gastroenterol] Full Article

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Mochida Files New Drug Application for MD-0901, a Once-Daily Treatment for Ulcerative Colitis, in Japan
Mochida Pharmaceutical Co., Ltd. announced that the company filed a new drug application for MD-0901, for the treatment of patients with ulcerative colitis with the Japanese Ministry of Health, Labour and Welfare. [Mochida Pharmaceutical Col., Ltd.] Press Release

Ironwood and Allergan Initiate Phase IIb Clinical Trial of Linaclotide Colonic Release in Adults with Irritable Bowel Syndrome with Constipation
Ironwood Pharmaceuticals, Inc. and Allergan plc announced the initiation of a Phase IIb clinical trial evaluating two orally-administered colonic release formulations of linaclotide in adult patients with irritable bowel syndrome with constipation. [Ironwood Pharmaceuticals, Inc.] Press Release

German and US Partners Join Forces in Stem Cell Research to Accelerate Development of New Therapies
Researchers at The Scripps Research Institute in California, USA, and two German institutes, the Center for Integrated Psychiatry Kiel and the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, announced a partnership to advance the quality control of human stem cells. [The Scripps Research Institute] Press Release

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Canada Creates Science-Minister Post
Canada’s new prime minister, Justin Trudeau, created the post of Minister of Science as one of his first acts. Kirsty Duncan, a medical geographer at the University of Toronto, will be the first to hold the job. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW German Cancer Congress 2016
February 24-27, 2016
Berlin, Germany

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Fellow – Immunology or Genetics (Research Center for Molecular Medicine of the Austrian Academy of Sciences)

NEW Postdoctoral Associate – Epigenetics of Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

NEW Open Group Leader Position – Cancer Research (Oslo University Hospital)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

Postdoctoral Scientist – Cancer Biology, Immunology and Gastrointestinal Research (Cedars-Sinai)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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