Volume 1.34 | Nov 13

Intestinal Cell News 1.34 November 13, 2015
Intestinal Cell News
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Vitamin C Halts Growth of Aggressive Forms of Colorectal Cancer in Preclinical Study
Researchers found that high doses of vitamin C—roughly equivalent to the levels found in 300 oranges—impaired the growth of KRAS mutant and BRAF mutant colorectal tumors in cultured cells and mice. The findings could lead to the development of new treatments and provide critical insights into who would most benefit from them. [Press release from Weill Cornell Medical College discussing online publication in Science]
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PUBLICATIONS (Ranked by impact factor of the journal)

A Gut-Vascular Barrier Controls the Systemic Dissemination of Bacteria
Investigators identified a gut-vascular barrier in mice and humans that controls the translocation of antigens into the blood stream and prohibits entry of the microbiota. [Science] Abstract | Press Release

The Localization of the Apical Par/Cdc42 Polarity Module Is Specifically Affected in Microvillus Inclusion Disease
The authors found that the polarity determinants Cdc42, Par6B, PKCζ/ι and the structural proteins ezrin and phospho-ezrin were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients. They performed Myo5B depletion in 3D-grown human Caco2 cells forming cysts and they found a direct link between the loss of Myo5B and the mislocalization of the same apical proteins [Biol Cell] Abstract

Chemopreventive Effect of Chalcone Derivative, L2H17, in Colon Cancer Development
Scientists evaluated the anti-cancer effects of the chalcone derivative, L2H17, in colon cancer cells. They showed that compound L2H17 exhibited selective cytotoxic effect on colon cancer cells, via inducing G0/G1 cell cycle arrest and apoptosis in CT26.WT cells [BMC Cancer] Full Article

SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells
Scientists determined that upon infection, the larger molecular weight proteins in human small intestinal epithelial host cells appeared to globally undergo tyrosine dephosphorylation. [PLoS One] Full Article

CDX2 Downregulation Is Associated with Poor Differentiation and MMR Deficiency in Colon Cancer
Researchers investigated Caudal-related homeobox transcription factor 2 (CDX2) mRNA and protein expression in relation to the clinicopathological characteristics of colon cancer, including mismatch repair status and recurrence risk. [Exp Mol Pathol] Abstract

Indomethacin-Induced Intestinal Epithelial Cell Damage Is Mediated by pVHL Activation through the Degradation of Collagen I and HIF-1α
The authors examined whether indomethacin treatment affects pVHL expression in the rat IEC6 intestinal epithelial cell line. [Biochem Biophys Res Commun] Abstract

Generation of a Human Antibody that Inhibits TSPAN8-Mediated Invasion of Metastatic Colorectal Cancer Cells
Investigators identified a large extracellular loop of tetraspanin 8 (TSPAN8) as a key domain for regulating metastatic colorectal cancer invasion. [Biochem Biophys Res Commun] Abstract


Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Researchers showed that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1+ stem cells served as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. [Cancer Cell] Abstract | Graphical Abstract

Generation of Enterocyte-Like Cells from Human Induced Pluripotent Stem Cells for Drug Absorption and Metabolism Studies in Human Small Intestine
Researchers generated enterocyte-like cells from human induced pluripotent stem cells, which are applicable to drug absorption and metabolism studies. [Sci Rep] Full Article

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Therapeutic Targets in the Wnt Signaling Pathway: Feasibility of Targeting TNIK in Colorectal Cancer
TRAF2- and NCK-interacting protein kinase (TNIK) regulates Wnt signaling in the most downstream part of the pathway, and its inhibition is expected to block the signal even in colorectal cancer cells with adenomatous polyposis coli gene mutation. The authors discuss some of the TNIK inhibitors under preclinical development. [Pharmacol Ther] Abstract

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Boehringer Ingelheim Partners with Leading Scientific Institutions in Inflammatory Bowel Disease Research
Boehringer Ingelheim announced new collaborations with four major scientific partners to enrich research and development of novel therapeutic approaches for patients with inflammatory bowel disease, including the Icahn School of Medicine at Mount Sinai, Massachusetts General Hospital, Scripps Research Institute and Weill Cornell Medicine. [Boehringer Ingelheim GmbH] Press Release

10th Double Helix Medals Dinner Raises Record $4.5 Million for Biomedical Research at Cold Spring Harbor Laboratory
More than $4.5 million was raised at Cold Spring Harbor Laboratory’s 10th Double Helix Medals dinner. [Cold Spring Harbor Laboratory] Press Release

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National Institutes of Health (United States)

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Therapeutic Goods Administration (Australia)
NEW 3rd St. Gallen International Gastrointestinal Cancer Conference (GICC)
March 10-12, 2016
St. Gallen, Switzerland

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Fellowship – Innate Lymphoid Cell-Epithelial Cell Interactions in Intestinal Lymphoid Follicles (Linköping University)

NEW PhD Studentships – Cancer Research (Institute of Cancer Research)

NEW Computational Postdoctoral Associate – Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Immunology or Genetics (Research Center for Molecular Medicine of the Austrian Academy of Sciences)

Postdoctoral Associate – Epigenetics of Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Open Group Leader Position – Cancer Research (Oslo University Hospital)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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