Volume 1.30 | Oct 16

Intestinal Cell News 1.30 October 16, 2015
Intestinal Cell News
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The Consensus Molecular Subtypes of Colorectal Cancer
To resolve inconsistencies among the reported gene expression–based colorectal cancer classifications and facilitate clinical translation, investigators formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. [Nat Med] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)

Clinical Significance of SNORA42 as an Oncogene and a Prognostic Biomarker in Colorectal Cancer
Scientists systematically evaluated dysregulation of small nucleolar RNAs in colorectal cancer (CRC) and clarified their biomarker potential and biological significance in CRC. [Gut] Abstract | Press Release

Preserved Genetic Diversity in Organoids Cultured from Biopsies of Human Colorectal Cancer Metastases
Tumor biopsies were obtained from 14 patients with metastatic colorectal cancer to test the feasibility of organoid culture from metastatic biopsy specimens and to compare the genetic diversity of patient-derived tumor organoids and the original tumor biopsy. [Proc Natl Acad Sci USA] Abstract

SPROUTY-2 Represses the Epithelial Phenotype of Colon Carcinoma Cells via Upregulation of ZEB1 Mediated by ETS1 and miR-200/miR-150
Researchers have dissected SPROUTY-2 (SPRY2) action in human colon cancer. Global transcriptomic analyses show that SPRY2 downregulates genes encoding tight junction proteins such as claudin-7 and occludin and other cell-to-cell and cell-to-matrix adhesion molecules in human SW480-ADH colon carcinoma cells. [Oncogene] Abstract

JRK Is a Positive Regulator of β-Catenin Transcriptional Activity Commonly Overexpressed in Colon, Breast and Ovarian Cancer
Scientists interrogated a highly validated genomic screen and the largest repository of cancer genomics data and identified JRK as a potential new oncogene and therapeutic target of the β-catenin pathway. They then validated the oncogenic role of JRK in colon cancer cells and primary tumors. [Oncogene] Abstract

Antitumor Activity of a Potent MEK Inhibitor, TAK-733, against Colorectal Cancer Cell Lines and Patient Derived Xenografts
In a preclinical study of TAK-733, a panel of CRC cell lines were exposed to varying concentrations of the agent for 72 hours followed by a sulforhodamine B assay. The MEK inhibitor TAK-733 demonstrated robust antitumor activity against CRC cell lines and patient-derived tumor explants. [Oncotarget] Full Article | Press Release

Assessment of a HER2 Scoring System for Colorectal Cancer: Results from a Validation Study
The authors sought to develop criteria for ERBB2-positivity (HER2) in colorectal cancer to ensure accurate identification of ERBB2-amplified metastatic colorectal cancer patients suitable for enrolment in a Phase II trial of ERBB2-targeted therapy. [Mod Pathol] Abstract

Inhibition of Topoisomerase II by Phase II Metabolites of Resveratrol in Human Colon Cancer Cells
The cytotoxic and genotoxic potential of phase II metabolites of resveratrol was investigated in human colon cells with special emphasis on human topoisomerase II. [Mol Nutr Food Res] Abstract

Neuron Navigator 2 Overexpression Indicates Poor Prognosis of Colorectal Cancer and Promotes Invasion through the SSH1L/Cofilin-1 Pathway
Scientists sought to understand the prognostic value of neuron navigator 2 (NAV2) expression in colorectal cancer (CRC) patients and the potential pathway through which NAV2 promotes migration and invasion in CRC cell lines. [J Exp Clin Cancer Res] Full Article

Butyrate Inhibits Pro-Proliferative miR-92a by Diminishing c-Myc-Induced miR-17-92a Cluster Transcription in Human Colon Cancer Cells
Previous reports indicate these actions are mediated in part by altered levels of miRNAs, including suppressed expression of the oncogenic miR-17-92a cluster. Investigators sought to identify the mechanisms underlying these effects of butyrate in colon cancer. [Mol Cancer] Full Article


Evidence of Absorptive Function In Vivo in a Neo-Formed Bio-Artificial Intestinal Segment Using a Rodent Model
A previously developed neo-formed bio-artificial intestinal segment (BIS) was constructed with the intervention of naïve stem cells that repopulated the scaffold in vivo, and over a period of time, were transformed in different cell populations typical of normal intestinal mucosa. Here, scientists aimed to demonstrate that the BIS generated has functional absorptive capacity. [J Gastrointest Surg] Abstract

Generation of Tissue-Engineered Small Intestine Using Embryonic Stem Cell-Derived Human Intestinal Organoids
Scientists investigated the ability of human embryonic stem cells or human intestinal organoids to populate acellular porcine intestinal matrices and artificial polyglycolic/poly L lactic acid scaffolds, and examined the ability of matrix/scaffolds to thrive when transplanted in vivo. [Biol Open] Full Article

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Targeting Colorectal Cancer Stem Cells Using Curcumin and Curcumin Analogues: Insights into the Mechanism of the Therapeutic Efficacy
Curcumin and its analogs have also recently been shown to be effective in lowering tumor recurrence by targeting the cancer stem cell (CSC) population, hence inhibiting tumor growth. The authors highlight the efficacy of curcumin and its analogues in targeting colorectal CSCs and also the underlying molecular mechanism involved. [Cancer Cell Int] Full Article

Visit our reviews page to see a complete list of reviews in the Intestinal Cell research field.
Researchers Use Gut Bacteria Composition to Genetically Classify Colorectal Tumors
By analyzing the types of gut bacteria present around colorectal tumors, researchers have found a way to predict key genetic mutations in the tumors themselves, a method that could eventually inform the development of colorectal cancer diagnostics and therapeutics. [Press release from the American Society of Human Genetics (ASHG) discussing research presented at the ASHG 2015 Meeting, Baltimore]
Press Release | Abstract

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Cancer Research UK Launches £100 Million Grand Challenges to Tackle the Most Important Questions in Cancer
Cancer Research UK has launched Grand Challenges – the biggest and most ambitious cancer grants in the world – which aim to overcome the greatest barriers standing in the way of beating cancer. The £100 million investment will revolutionize how researchers diagnose, prevent and treat cancer by uniting teams of the best scientists around the world to come up with answers to crucial questions about how to save more lives from cancer. [Cancer Research UK] Press Release

NC Researchers Awarded $5.3 Million to Develop Novel Gut-on-a-Chip Technology
A team of researchers from the University of North Carolina at Chapel Hill and NC State University has received a $5.3 million, five-year Transformative Research Award from the National Institutes of Health to create fully functioning versions of the human gut that fit on a chip the size of a dime. [University of North Carolina at Chapel Hill School of Medicine] Press Release

Georgia State Researcher Gets $1.35 Million to Study Effects of Common Food Additive on Body
Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.35 million federal grant to study how emulsifiers affect bacteria in the intestinal tract and cause chronic inflammatory diseases in the gut. [Georgia State University] Press Release

Harry Winston, Inc. and Mattel Children’s Hospital UCLA Announce New Fellows
Harry Winston, Inc. and the UCLA Children’s Discovery and Innovation Institute have named the new recipients of the 2015-2016 Harry Winston Fellowships. The fellowships support the work of young pediatric physician-scientists from Mattel Children’s Hospital UCLA who are conducting research to prevent, treat and cure disease and illness in children. [UCLA Health] Press Release
Researcher Calls for Changes to Current Colorectal Cancer Screening Guidelines
Screening is the most effective way to reduce the risk of dying from the disease, yet current recommendations to screen older people with a family history of colorectal cancer, specifically with colonoscopy every five years, is not justified for most patients. [Penn Medicine] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cells: Development & Management
November 30-December 2, 2015
Phitsanulok, Thailand

Visit our events page to see a complete list of events in the Intestinal Cell research community.
NEW Postdoctoral Scientist – Cancer Biology, Immunology and Gastrointestinal Research (Cedars-Sinai)

NEW Postdoctoral Research Officer – Colon Cancer and Intestinal Development (Hudson Institute of Medical Research)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Project Manager – Manufacturing (Qu Biologics)

Postdoctoral Research Fellow/Research Scientist – Biotechnology (Qu Biologics)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

PhD Positions – Gut Microbiota and Colon Cancer (University of Southern Denmark)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Research Fellow – Colorectal Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

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