Volume 6.23 | June 26

2020-26-06 | ICN 6.23
Intestinal Cell News by STEMCELL Technologies
Vol. 6.23 – 26 June, 2020

Spermine Synthase and MYC Cooperate to Maintain Colorectal Cancer Cell Survival by Repressing Bim Expression

Researchers uncovered a key survival signal in colorectal cancer through convergent repression of Bim expression by distinct spermine synthase and MYC-mediated signaling pathways.
[Nature Communications]

Full Article

Watch 'collaborating to accelerate COVID-19 research'
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Exosomes Transfer miRNAas from Cell-To-Cell to Inhibit Autophagy During Infection with Crohn’s Disease-Associated Adherent-Invasive E. coli

Investigators showed that upon Adherent-invasive E. coli (AIEC) infection, intestinal epithelial cells (IECs) secreted exosomes that could transfer specific miRNAs to recipient IECs, inhibiting autophagy-mediated clearance of intracellular AIEC.
[Gut Microbes]


MiR-200b in Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviates Inflammatory Injury of Intestinal Epithelial Cells by Targeting High Mobility Group Box 3

Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury.
[Cell Death & Disease]

Full Article

Enalapril Overcomes Chemoresistance and Potentiates Antitumor Efficacy of 5-FU in Colorectal Cancer by Suppressing Proliferation, Angiogenesis, and NF-κB/stat3-Regulated Proteins

Researchers verified enalapril, a clinically widely used antihypertensive and anti-heart failure drug, as a chemosensitizer that improved sensitivity of colorectal cancer cells to 5-Fluorouracil.
[Cell Death & Disease]

Full Article

Wnt-Driven LARGE2 Mediates Laminin-Adhesive O-Glycosylation in Human Colonic Epithelial Cells and Colorectal Cancer

Investigators revealed that Wnt activity triggered the expression of the gene, LARGE2, which in turn mediated the laminin- adhesive O-glycosylation of α-DG. They found abnormally increased cellular adhesion to laminin during Wnt-driven cancer progression.
[Cell Communication and Signaling]

Full ArticleGraphical Abstract

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

The authors demonstrated that the artificial sweeteners sucralose, aspartame, and saccharin exerted a range of negative effects on the intestinal epithelium through the sweet taste receptor T1R3.

Full Article

CD47 Is a Negative Regulator of Intestinal Epithelial Cell Self-Renewal Following DSS-Induced Experimental Colitis

Researchers revealed CD47 as a negative regulator in intestinal epithelial cell renewal during colitis through downregulating OSKM transcriptional factors.
[Scientific Reports]

Full Article

PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells

Scientists suggested that the pre-mRNA processing factor 4B kinase domain was responsible for promoting drug resistance to curcumin by inducing EMT.
[Molecules and Cells]


Amending Microbiota by Targeting Intestinal Inflammation with TNF Blockade Attenuates Development of Colorectal Cancer

Using chemically induced and spontaneous mouse colorectal cancer (CRC) models colonized by colibactin-producing Escherichia coli, scientists established the role of microbiota in mediating the antitumorigenic effect of anti–tumor necrosis factor therapy.
[Nature Cancer]


Tumors Are 3D. Your 2D Model May Not Give You All The Answers. Learn More.

Ageing, Metabolism and the Intestine

The authors review the current state of research of how metabolism and ageing control intestinal stem cell function and epithelial homeostasis.
[EMBO Reports]

Full Article


Natera Announces First Patient Enrollments in Both CIRCULATE-Japan and BESPOKE CRC Trials Using SignateraTM MRD Testing

Natera, Inc. announced that enrollment has begun in the CIRCULATE-Japan and BESPOKE CRC trials, with both studies experiencing strong interest from centers across Japan and the U.S. The studies will measure clinical outcomes of Signatera molecular residual disease testing in resectable stages II-IV colorectal cancer.

Press Release

NIH’s New Sexual-Harassment Rules are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behaviour, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]


Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.



Crohn’s and Colitis Congress 2021

1/21/2021 – 1/23/2021
Las Vegas, Nevada, United States

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Postdoctoral Associate – Molecular and Human Genetics

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Position – Gastrointestinal Disorders

KU Leuven – Leuven, Belgium

Lab Manager – Intestinal Research

Howard Hughes Medical Institute – Chevy Chase, Maryland, United States

Research Scientist – Oncology

Gilead Sciences, Inc. – Seattle, Washington, United States

Cancer Biology Invesigator – Cancer Epigenetics

GSK – Collegeville, Pennsylvania, United States

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