Volume 6.22 | June 19

2020-06-19 | ICN 6.22
Intestinal Cell News by STEMCELL Technologies
Vol. 6.22 – 19 June, 2020

Lineage Reversion Drives WNT Independence in Intestinal Cancer

Scientists showed that while WNT suppression blocked tumor growth in most organoid and in vivo colorectal cancer (CRC) models, the accumulation of CRC-associated genetic alterations enabled drug resistance and WNT-independent growth.
[Cancer Discovery]


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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.

AbstractPress ReleaseGraphical Abstract

Glucagon like Peptide-2 for Intestinal Stem Cell and Paneth Cell Repair during Graft-Versus-Host Disease in Mice and Humans

Researchers found that L-cells were a target of acute graft-versus-host disease (GVHD) and that glucagon-like-peptide-2-based treatment of acute GVHD restored intestinal homeostasis via an increase of intestinal stem cells and paneth cells without impairing graft-versus-leukemia effects.


SphK2 Confers 5-Fluorouracil Resistance to Colorectal Cancer via Upregulating H3K56ac-Mediated DPD Expression

Investigators showed that SphK2high conferred 5-fluorouracil resistance through upregulated tumoral dihydropyrimidine dehydrogenase.


MicroRNA-17-5p Regulates EMT by Targeting Vimentin in Colorectal Cancer

The authors demonstrated that miRNA-17-5p regulated vimentin expression, thereby regulating metastasis of colorectal cancer.
[British Journal of Cancer]


LncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer

Scientists identified the underlying role of MT1M-related noncoding RNA STEAP3-AS1 in colon cancer progression.
[Molecular Therapy-Nucleic Acids]

AbstractGraphical Abstract

FGFR4 Increases EGFR Signaling by Inducing AREG Expression and Attenuates Response to EGFR Inhibitors in Colon Cancer

Researchers investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti‐EGFR therapy in colon cancer treatment.
[Cancer Science]


Latexin Deficiency in Mice Up-Regulates Inflammation and Aggravates Colitis through hECTD1/Rps3/Nf-κB Pathway

Ectopic expression of Latexin led to IκBα accumulation in intestinal epithelial cells, however, latexin knockdown enhanced the interaction of HECTD1 and Rps3, contributing to the ubiquitination degradation of IκBα, and subsequently enhanced inflammatory response.
[Scientific Reports]

Full Article

Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers showed that tumor-stroma co-cultures consisting of aligned extracellular matrix fibers and ordered micro-architecture induced an epithelial phenotype in colorectal cancer cells while disordered extracellular matrix drove a mesenchymal phenotype, similar to well and poorly differentiated tumors, respectively.
[Scientific Reports]

Full Article

Zeb2 Drives Invasive and Microbiota-Dependent Colon Carcinoma

Scientists identified a synergistic inflammatory tumor-promoting mechanism through which resident intestinal microbiota boosts invasive colorectal cancer cell development in an epithelial-to-mesenchymal transition-prone tissue environment.
[nature cancer]


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BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.

AbstractFull ArticleGraphical Abstract


Devonian Health Group Announces Notice of Allowance for a US Patent Application Covering Use of Thykamine for the Treatment of Ulcerative Colitis

Devonian Health Group, Inc. announced today that the United States Patent and Trademark Office has issued a Notice of Allowance for U.S patent application titled, “Thylakoid Extract Composition and Formulation for the Treatment of Inflammatory Bowel Disease,” covering the use of Thykamine™ for the treatment of ulcerative colitis.

Press Release

US Science Groups Wary of New Senate Bills to Curb Foreign Influences

A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.


Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.



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Cancer Biology Invesigator – Cancer Epigenetics

GSK – Collegeville, Pennsylvania, United States

Postdoctoral Associate – Molecular and Human Genetics

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Research Fellow – Molecular Oncology

Genetech, Inc. – South San Francisco, California, United States

Research Scientist – Oncology

Gilead Sciences, Inc. – Seattle, Washington, United States

Postdoctoral Position – Gastrointestinal Disorders

KU Leuven – Leuven, Belgium

Postdoctoral Fellow – Cancer Biology

Augusta University – Augusta, Georgia, United States

Postdoctoral Fellow – Cancer Development

NIH National Institute of Diabetes and Digestive and Kidney Diseases – Bethesda, Maryland, United States

Lab Manager – Intestinal Research

Howard Hughes Medical Institute – Chevy Chase, Maryland, United States

Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal

Surrozen, Inc. – South San Francisco, California, United States

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