Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Cancer-Derived Exosomal Alu RNA Promotes Colorectal Cancer Progression

[Experimental & Molecular Medicine] Researchers discovered that Alu RNA induced epithelial-to-mesenchymal transition through nucleotide-binding domain leucine-rich repeat containing 3 inflammasome activation and IL-1β release in colorectal cancer cells.

RNF166 Promotes Colorectal Cancer Progression by Recognizing and Destabilizing Poly-ADP-Ribosylated Angiomotins

[Cell Death & Disease] Investigators uncovered the involvement of an upregulated E3 ubiquitin ligase called RNF166, which destabilized angiomotins, activated yes-associated protein, and was associated with a poor prognosis in colorectal cancer patients.

Role of Protein Degradation Systems in Colorectal Cancer

[Cell Death Discovery] The authors provide a comprehensive overview of the dual roles played by the ubiquitin‒proteasome system and autolysosome system in colorectal cancer, elucidating their impact on the initiation and progression of this disease while also highlighting their compensatory relationship.

Epidermal Growth Factor Receptor (EGFR) Is a Target of the Tumor-Suppressor E3 Ligase FBXW7

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators used CRISPR base editors to introduce different FBXW7 hotspot mutations in human colon organoids.

Notoginsenoside R1 Promotes Lgr5+ Stem Cell and Epithelium Renovation in Colitis Mice via Activating Wnt/β-Catenin Signaling

[Acta Pharmacologica Sinica] Using a dextran sulfate sodium salt (DSS)-induced colitis mouse model, scientists investigated the reparative effects of notoginsenoside R1 on mucosal barrier damage after the acute injury stage of DSS exposure.

JAK/STAT3 Represents a Therapeutic Target for Colorectal Cancer Patients with Stromal-Rich Tumors

[Journal Of Experimental & Clinical Cancer Research] Scientists investigated the use of JAK inhibitors for anti-cancer activity in coloretal cancer cell lines, mouse model organoids and patient-derived organoids.

Identifying Regulators of Aberrant Stem Cell and Differentiation Activity in Colorectal Cancer Using a Dual Endogenous Reporter System

[Nature Communications] Researchers engineered a dual endogenous reporter system by genome-editing the SOX9 and KRT20 loci of human colorectal cancer cell lines to express fluorescent reporters, broadcasting aberrant stem cell-like and differentiation activity, respectively.

Johnson & Johnson Submits Supplemental Biologics License Application to U.S. FDA Seeking Approval of TREMFYA®(guselkumab) for the Treatment of Adults with Moderately to Severely...

[Johnson & Johnson] Johnson & Johnson announced the submission of a supplemental Biologics License Application to the US FDA seeking approval of TREMFYA® for treatment of adults with moderately to severely active ulcerative colitis.

Researchers Awarded £2.6M to Develop Preclinical Lead Drug Candidate for Advanced Prostate and Colorectal Cancers

[University of Strathclyde] Researchers at the University of Strathclyde have been awarded £2.6 million to develop a preclinical lead drug candidate targeted at advanced prostate and colorectal cancers.

SLC26A9 Promotes Colorectal Tumorigenesis by Modulating Wnt/β-Catenin Signaling

[Cell Death Discovery] Researchers explored the role of solute carrier family 26 member 9 (SLC26A9) in colorectal cancer (CRC) and its related mechanisms through clinical samples from CRC patients, CRC cell lines and mouse models.

Improved Detection of Colibactin-Induced Mutations by Genotoxic E. coli in Organoids and Colorectal Cancer

[Cancer Cell] Co-culture of intestinal organoids with a colibactin-producing polyketide synthase E. coli strain revealed mutational signatures also found in colorectal cancer.

Inhibition of the AURKA/YAP1 Axis Is a Promising Therapeutic Option for Overcoming Cetuximab Resistance in Colorectal Cancer Stem Cells

[British Journal Of Cancer] The authors used transcriptomic analysis along with in vitro and in vivo models of RAS/RAF wild-type CRC to study YAP1 Ser397 phosphorylation as a potential biomarker for cetuximab resistance.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.

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