Volume 2.17 | May 13

Intestinal Cell News 2.17 May 13, 2017
Intestinal Cell News
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Lactase Nonpersistence Is Directed by DNA-Variation-Dependent Epigenetic Aging
Scientists performed a comprehensive epigenetic study of human and mouse small intestines, by using chromosome-wide DNA-modification profiling and targeted bisulfite sequencing. Epigenetically controlled regulatory elements accounted for the differences in lactase mRNA levels among individuals, intestinal cell types and species. [Nat Struct Mol Biol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

A Microfluidics-Based In Vitro Model of the Gastrointestinal Human–Microbe Interface
Scientists present a modular, microfluidics-based model, which allows co-culture of human and microbial cells under conditions representative of the gastrointestinal human–microbe interface. [Nat Commun] Full Article

Opposing Roles of Nuclear Receptor HNF4α Isoforms in Colitis and Colitis-Associated Colon Cancer
Investigators showed that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colonic crypt and P2-HNF4α in the proliferative compartment. [eLife] Abstract | Download Full Article

FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor Suppressive miR-342 in Human Colorectal Cancer
The authors performed a systematic and comprehensive discovery step by evaluating the expression of FOX family members, and identified that FOXM1 and FOXQ1 are frequently overexpressed in colorectal cancer. [Clin Cancer Res] Abstract

Cancer Stem-Like Properties in Colorectal Cancer Cells with Low Proteasome Activity
Investigators elucidated the relationship between low proteasome activity cells (LPACs) and cancer stem-like cells (CSCs). LPACs have characteristic treatment resistance and act as CSCs in colorectal cancer. [Clin Cancer Res] Abstract

Non-Tumor Tissue Derived Interleukin-17B Activates IL-17RB/AKT/β-Catenin Pathway to Enhance the Stemness of Gastric Cancer
Scientists confirmed that the expression of interleukin (IL)-17RB in gastric cancer tissues was significantly increased, that overexpression was associated with poor prognosis of gastric cancer patients, and that overexpression was positively correlated with some stemness markers. [Sci Rep] Full Article

An Oncogenic Role of miR-592 in Tumorigenesis of Human Colorectal Cancer by Targeting Forkhead Box O3A (FoxO3A)
Researchers interrogated the biological significance of miR-592 in colorectal cancer (CRC). A striking upregulation of miR-592 was observed in CRC tissues and cell lines compared to the matched adjacent non-tumor tissues and normal colon cells. [Expert Opin Ther Targets] Abstract

Cellular Zinc Is Required for Intestinal Epithelial Barrier Maintenance via the Regulation of Claudin-3 and Occludin Expression
The authors investigated the essential roles of intracellular zinc in the preservation of intestinal tight junction integrity and the underlying molecular mechanisms. [Am J Physiol Gastrointest Liver Physiol] Abstract


Suppression of Intestinal Tumors by Targeting the Mitotic Spindle of Intestinal Stem Cells
Using organoid cultures established from conditional knockout mice and in vitro gene ablation, scientists showed that adenomatous polyposis coli inactivation led to aberrant intestinal stem cells proliferation and the expansion of the crypt domain. [Oncogene] Abstract

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The Hippo Pathway in Intestinal Regeneration and Disease
Researchers summarize studies on the role of the Hippo pathway in the intestine on these physiological processes and the underlying mechanisms responsible, and discuss future research directions and potential therapeutic strategies targeting Hippo signaling in intestinal disease. [Nat Rev Gastroenterol Hepatol] Abstract

The Third Dimension: New Developments in Cell Culture Models for Colorectal Research
The authors provide an overview on the potential applications but also on the limitations for each of these techniques, while evaluating their contribution to provide more reliable cellular models for research, diagnostic testing, or pharmacological validation related to colon physiology and pathophysiology. [Cell Mol Life Sci] Abstract

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VAXIMM Initiates Phase IIa Study in Advanced Colorectal Cancer with Oral T-Cell Vaccine VXM01
VAXIMM AG announced the enrollment of the first patient in a Phase IIa clinical trial. The study will enroll 24 patients with metastatic colorectal cancer whose disease has progressed following one or two prior therapies. [VAXIMM AG] Press Release

Seres Therapeutics Announces Academic Collaborations to Support Development of Microbiome Therapeutics for Inflammatory Bowel Disease
Seres Therapeutics, Inc. announced it has entered into two separate research collaborations with leading academic groups to support Seres’ ongoing development of the first potential microbiome therapeutics for inflammatory bowel disease. [Seres Therapeutics, Inc.] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Signaling in Cancer: From Mechanisms to Therapy
June 5-10, 2016
Snowmass Village, United States

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NEW Postdoctoral Position – Human Systems Immunology, Gut Inflammation and IBD (University College Cork)

Postdoctoral Position – Gut Microbiota and Colon Cancer (University of Southern Denmark)

Associate Director – Intestinal Microbiota (Institute for Basic Science/POSTECH)

Junior Principle Investigator – Gut Immunology (Institute for Basic Science/POSTECH)

Postdoctoral Fellow – Norovirus-Intestinal Microbiota Interactions (University of Florida)

Postdoctoral Fellow – Bioinformatics in Host-Microbiota Interactions (Wellcome Trust Sanger Institute)

PhD Studentship – Gut Bacterial Metabolism (Katholieke Universiteit Leuven)

Research Assistant – Autoimmune/Cell Biology (Immunocore Ltd)

Faculty Positions – Clinical Immunology (Oklahoma Medical Research Foundation)

Grant Writer (Gladstone Institutes)

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