Volume 2.16 | May 6

Intestinal Cell News 2.16 May 6, 2016
Intestinal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Study Shows Ozanimod as Effective in Treating Ulcerative Colitis
Researchers have shown that ozanimod, a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. This new class of immunotherapy drug traps white blood cells in the lymph nodes to prevent their escape into the gut where they cause inflammation. [Press release from University of California San Diego School of Medicine discussing online publication in the New England Journal of Medicine]
Press Release | Abstract
Cryopreservation Media for Stem Cells - Learn More!
 
PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

The EGFR-Specific Antibody Cetuximab Combined with Chemotherapy Triggers Immunogenic Cell Death
Scientists found that cetuximab, in combination with chemotherapy, fostered immunogenic cell death in colorectal cancer cells, which was measured via the endoplasmic reticulum stress response and an increase in phagocytosis by dendritic cells. [Nat Med] Abstract

Targeting TYRO3 Inhibits Epithelial-Mesenchymal Transition and Increases Drug Sensitivity in Colon Cancer
Investigators identified TYRO3 as a potential oncogene. Immunohistochemical staining results demonstrated that levels of TYRO3 were markedly elevated in polyps and colon cancer cells and were negatively correlated with prognosis. [Oncogene] Abstract

Ninjurin1 Inhibits Colitis-Mediated Colon Cancer Development and Growth by Suppression of Macrophage Infiltration through Repression of FAK Signaling
The authors used transgenic mice (tg mice) that overexpressed ninjurin1 on macrophages. They subjected ninjurin1 tg mice to a well-known mouse model of colitis-associated colon cancer in which animals are treated with azoxymethane and dextran sulfate sodium. [Oncotarget] Full Article

The Arachidonic Acid Metabolite 11β-ProstaglandinF2α Controls Intestinal Epithelial Healing: Deficiency in Patients with Crohn’s Disease
Enteric glial cells (EGC) isolated from crohn’s disease (CD) and control patients showed similar expression of glial markers and EGC-derived soluble factors (IL6, TGF-beta, proEGF, GSH) but CD EGC failed to increase intestinal epithelial barrier resistance and healing. [Sci Rep] Full Article

Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NFκB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β
The chemopreventive effects of garlic may be attributed to the anti-inflammatory properties of garlic’s sulfur-containing constituents, which includes DADS. Scientists demonstrated that DADS prevented colorectal tumorigenesis in a mouse model of colitis-induced colorectal cancer. [Cancer Prev Res] Abstract

Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis
Investigators examined the effects of serum-derived bovine immunoglobulin/protein isolate on mucosal inflammation in mdr1a-/- mice that spontaneously develop colitis. [PLoS One] Full Article

INTESTINAL STEM CELL & ORGANOID RESEARCH

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response
To investigate the effect of DNA demethylation on tumor organoids, researchers established organoids from intestinal tumors of ApcMin/+ mice and subjected them to 5-aza-2′-deoxycytidine treatment and Dnmt1 knockdown. [Sci Rep] Full Article

Full-Length LGR5-Positive Cells Have Chemoresistant Characteristics in Colorectal Cancer
Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signaling and considered both a cancer stem cell marker and intestinal stem cell marker. Scientists found first some splice variants of LGR5 in human intestine and elucidated the functional feature of full-length LGR5. [Br J Cancer] Abstract

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
Intestinal Stem Cell Response to Injury: Lessons from Drosophila
The authors review the current understanding of the mechanisms that control intestinal stem cell (ISC) self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury. [Cell Mol Life Sci] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
 
SCIENCE NEWS
Radiation and Immunotherapy Combination Can Destroy Both Primary and Secondary Tumors
Scientists describe how a combination of radiation therapy and L19-IL2, an immunotherapy agent, can increase significantly the immune response when given to mice with primary colorectal tumors. [Press release from European Society for Radiotherapy and Oncology (ESTRO) (EurekAlert!) discussing research to be presented at the ESTRO 35, Turin] Press Release

Genentech Highlights Personalized Medicines and Cancer Immunotherapies
Genentech announced new results from 19 approved and investigational medicines will be presented. More than 200 abstracts have been accepted across eight cancer types, including four “late breakers” and nearly 30 oral presentations. [Press release from Genentech, Inc. discussing research to be presented at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting, Chicago] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
 
INDUSTRY NEWS
Government of Canada Combats Chronic Health Conditions
The Honorable Jane Philpott, Minister of Health, announced an investment of $16 million over five years to support new research that will help find new ways to prevent or treat chronic conditions affecting millions of Canadians. [Government of Canada] Press Release

Celimmune Commences First-Ever Dosing with AMG 714 in Celiac Disease
Celimmune LLC announced that it has dosed the first patient in its Phase II clinical study for AMG 714 in celiac disease. AMG 714 is an investigational anti-IL-15 monoclonal antibody being studied for the treatment of gluten-free diet non-responsive celiac disease and refractory celiac disease Type II. [Celimmune LLC] Press Release

Helsinn Announces Top-Line Results of Its Phase IIb Trial with Elsiglutide for the Prevention of Chemotherapy-Induced Diarrhea in Colorectal Cancer Patients
Helsinn announces top-line results from its clinical Phase IIb dose-finding trial to assess the efficacy of elsiglutide in the prevention of diarrhea induced by chemotherapy in patients with colorectal cancer. [Helsinn] Press Release
 
POLICY NEWS
Nine Years of Censorship
Canadian scientists are now allowed to speak out about their work — and the government policy that had restricted communications. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW International Agency for Research on Cancer (IARC) 50th Anniversary Conference
June 7-10, 2016
Lyon, France

Visit our events page to see a complete list of events in the intestinal cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Gut Microbiota and Colon Cancer (University of Southern Denmark)

NEW Associate Director – Intestinal Microbiota (Institute for Basic Science/POSTECH)

NEW Junior Principle Investigator – Gut Immunology (Institute for Basic Science/POSTECH)

NEW Postdoctoral Fellow – Norovirus-Intestinal Microbiota Interactions (University of Florida)

NEW Postdoctoral Fellow – Bioinformatics in Host-Microbiota Interactions (Wellcome Trust Sanger Institute)

NEW PhD Studentship – Gut Bacterial Metabolism (Katholieke Universiteit Leuven)

Postdoctoral Research Fellow – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

Research Assistant – Autoimmune/Cell Biology (Immunocore Ltd)

Faculty Positions – Clinical Immunology (Oklahoma Medical Research Foundation)

Grant Writer (Gladstone Institutes)


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