Volume 2.13 | Apr 15

Intestinal Cell News 2.13 April 15, 2016
Intestinal Cell News
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A Key Gene in the Development of Celiac Disease Has Been Found in ‘Junk’ DNA
A key gene in the regulation of the inflammatory response observed in celiac patients has been found in one of the regions of the junk genome: it is the lnc13. In celiacs, this non-coding RNA is hardly produced at all so the levels of these inflammatory genes are not properly regulated and their expression is increased. [Press release from University of the Basque Country discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3
The authors investigated the compartment-specific impact of IRAK-M on colorectal carcinogenesis using a mouse model. They demonstrated that IRAK-M is expressed in tumor cells due to combined TLR and Wnt activation. [Cancer Cell] Abstract | Graphical Abstract

Enteric Viruses Ameliorate Gut Inflammation via Toll-Like Receptor 3 and Toll-Like Receptor 7-Mediated Interferon-β Production
Researchers found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium-induced colitis compared with untreated mice. [Immunity] Abstract | Graphical Abstract

Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations
The authors demonstrated that Lipocalin-2 protects from early-onset colitis and spontaneous emergence of right-sided colonic tumors resulting from IL-10 deficiency. [Cell Host Microbe] Abstract | Graphical Abstract

A Long Non-Coding RNA Targets microRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division
Scientists report a novel long non-coding RNA, Lnc34a, that is enriched in colon cancer stem cells and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. [eLife] Abstract | Download Full Article

Physiological TLR5 Expression in the Intestine Is Regulated by Differential DNA Binding of Sp1/Sp3 through Simultaneous Sp1 Dephosphorylation and Sp3 Phosphorylation by Two Different PKC Isoforms
Researchers showed that butyrate transcriptionally upregulates toll-like receptor 5 (TLR5) in the intestinal epithelial cells and augments flagellin-induced immune responses. Both basal and butyrate-induced transcription was regulated by differential binding of Sp-family transcription factors to the GC-box sequences over the TLR5 promoter. [Nucleic Acids Res] Full Article

Tristetraprolin Inhibits Gastric Cancer Progression through Suppression of IL-33
Scientists report that Tristetraprolin suppressed the expression of interleukin-33 (IL-33), a tumor-promoting inflammatory cytokine, and thereby inhibited the progression of gastric cancer [Sci Rep] Full Article

Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients
Researchers developed a microfluidic device utilizing antibody-conjugated non-fouling coating to eliminate nonspecific binding and to promote the multivalent binding of target cells. By employing a sensitive device, circulating tumor cell counts showed good correlation with colorectal neoplasm. [Sci Rep] Full Article

TAK1 Regulates Paneth Cell Integrity Partly through Blocking Necroptosis
Investigators found that depletion of gut bacteria or myeloid differentiation factor 88, a mediator of bacteria-derived cell signaling, reduced reactive oxygen species (ROS) but did not block Paneth cell loss, suggesting that gut bacteria are the cause of ROS accumulation but bacteria-induced ROS are not the cause of Paneth cell loss. [Cell Death Dis] Abstract


Simultaneous Control of Stemness and Differentiation by the Transcription Factor Escargot in Adult Stem Cells: How Can We Tease Them Apart?
Escargot maintained stemness of intestinal stem cells while regulating the terminal differentiation of progenitor cells into absorptive enterocytes or secretory enteroendocrine cells. [Fly (Austin)] Abstract

Fbxw7-Associated Drug Resistance Is Reversed by Induction of Terminal Differentiation in Murine Intestinal Organoid Culture
Investigators studied genetically engineered mice in which the fbxw7 gene is conditionally knocked-out in the intestine (fbxw7ΔG). To further investigate the mechanism of Fbxw7-action, they grew intestinal crypts from floxed-fbxw7 and fbxw7ΔG mice, in a Matrigel-based organoid (mini-gut) culture. [Mol Ther Methods Clin Dev] Abstract

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Vimentin, Colon Cancer Progression and Resistance to Butyrate and Other HDACis
The authors discuss the hypothesis that vimentin is a key factor integrating epithelial to mesenchymal transition, colonic neoplastic progression and resistance to histone deacetylase inhibitors (HDACis). [J Cell Mol Med] Abstract

Epigenetics in Intestinal Epithelial Cell Renewal
The authors discuss recent discoveries on the role of the cellular epigenome in intestinal cell fate, development and tissue renewal. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Ludwig Scientists Share New Findings on Immunotherapy, Drug Resistance and Tumor Evolution
Research conducted by more than 70 Ludwig scientists will be presented in symposiums, plenaries and poster sessions, and Ludwig researchers will participate in several workshops and meet-the-expert sessions over the course of the meeting. [Press release from Ludwig Cancer Research discussing research to be presented at the 2016 American Association for Cancer Research (AACR) Annual Meeting, New Orleans] Press Release

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Penn Researcher to Lead $2.5 Million PCORI Project to Examine Dietary Interventions for Crohn’s Disease
A national research study to focus on diet as a tool for managing Crohn’s disease symptoms, led by James Lewis, MD, MSCE, a professor of Medicine and Epidemiology at the Perelman School of Medicine at the University of Pennsylvania, on behalf of the Crohn’s & Colitis Foundation of America, has been approved to receive a $2.5 million funding award by the Patient-Centered Outcomes Research Institute (PCORI). [Penn Medicine] Press Release

Gift Honors Dr. Ludwig and Helps Advance Cancer Research
A California businessman donated $1 million to the Medical College of Wisconsin to create an endowed chair to support research investigating the causes of colon cancer and its treatment. The gift was given to honor Kirk Ludwig, MD, GME ’94, chief of colorectal cancer at Froedtert & the Medical College of Wisconsin Clinical Cancer Center. [Medical College of Wisconsin] Press Release

University of Pennsylvania to Join First-of-Its-Kind Research Collaboration to Fight Cancer with New Immunotherapies
The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six of the nation’s top medical schools and cancer centers around a shared aim of accelerating breakthrough immunotherapy research that will turn more cancers into a curable disease. The venture is backed by a $250 million gift from the Parker Foundation, making it the largest single contribution ever made to the field of immunotherapy. [University of Pennsylvania] Press Release
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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Scientist – Inflammation (University of Oxford)

NEW Associate or Senior Editor – Epigenetics (Springer Nature)

NEW Faculty Positions – Clinical Immunology (Oklahoma Medical Research Foundation )

NEW Grant Writer (Gladstone Institutes)

PhD Studentship – Pectin in Human Intestinal Tract (Wageningen University)

PhD Studentship – Transcriptional Regulation in Colon Cancer (University of Helsinki)

Postdoctoral Scientist – Inflammation (University of Oxford)

Program Director – IBD and Crohn’s Disease Program (The Leona M. and Harry B. Helmsley Charitable Trust)

Postdoctoral Fellow – Nanomedicine (Johns Hopkins University)

Faculty Position – Cancer Research (Texas Tech University Health Sciences Center)

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