Volume 2.09 | Mar 11

Intestinal Cell News 2.09 March 11, 2016
Intestinal Cell News
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Notch1 and Notch2 Receptors Regulate Mouse and Human Gastric Antral Epithelial Cell Homoeostasis
Investigators tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Notch1 and Notch2 were the predominant Notch receptors expressed in mouse and human antral tissue and organoid cultures. [Gut] Abstract
Free wallchart: The Intestinal Crypt
PUBLICATIONS (Ranked by impact factor of the journal)

Topoisomerase IIα Mediates TCF-Dependent Epithelial-Mesenchymal Transition in Colon Cancer
T-cell factor (TCF) transcription induced epithelial-mesenchymal transition (EMT), promoting a tumor-initiating cell phenotype characterized by increased proliferation, multidrug resistance, invasion and metastasis. The authors characterized topoisomerase IIα as a required component of TCF transcription promoting EMT. [Oncogene] Full Article

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
Researchers showed that NLRX1 serves as a tumor suppressor in colitis-associated cancer and sporadic colon cancer by keeping key tumor promoting pathways in check. [Cell Rep]
Full Article | Graphical Abstract | Press Release

DDA1 Promotes Stage IIB-IIC Colon Cancer Progression by Activating NFκB/CSN2/GSK-3β Signaling
Scientists investigated whether DDA1 contributes to tumorigenesis and progression of stage II colon cancer via activation of the NFκB pathway. [Oncotarget] Full Article

Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads
Researchers recognized colon cancer stem cell (CSC) populations from colon cancer cells by using metabolic labeling of azido sugar based on the quiescent nature of these cells, which differed fundamentally from previously described methods by using specific cellular markers to recognize and isolate CSCs. [Anal Chem] Abstract

MiR-125a-5p Decreases after Long Non-Coding RNA HOTAIR Knockdown to Promote Cancer Cell Apoptosis by Releasing Caspase 2
The authors report that microRNA miR-125a-5p decreased and released caspase 2 to promote cancer cell apoptosis after HOTAIR knockdown. In 80 clinical colon cancer tissues, HOTAIR and miR-125a-5p levels were higher than adjacent tissues, whereas caspase 2 was lower. [Cell Death Dis] Full Article

GSH-Dependent Antioxidant Defense Contributes to the Acclimation of Colon Cancer Cells to Acidic Microenvironment
Investigators exposed colorectal cancer (CRC) cells to acidic pH continuously for over three months and obtained CRC cells that become acclimated to acidic pH, designated as CRC-acidosis-acclimated. [Cell Cycle] Abstract

Ulcerative Colitis-Associated Long Noncoding RNA, BC012900, Regulates Intestinal Epithelial Cell Apoptosis
Scientists aimed to determine whether long noncoding RNAs (lncRNAs) are associated with inflammatory bowel disease (IBD) and regulate epithelial cell physiology. Multiple lncRNAs are differentially expressed in IBD and play a role in regulating cellular physiology. [Inflamm Bowel Dis] Abstract


Bcl-2 Is a Critical Mediator of Intestinal Transformation
Investigators found that the NF-κB target Bcl-2, an anti-apoptotic gene, is specifically expressed in intestinal stem cells (ISCs) in both mice and humans. Bcl-2 is dispensable in homeostasis and, although involved in protecting ISCs from radiation-induced damage, it is non-essential in tissue regeneration. [Nat Commun] Full Article

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
Scientists systematically developed ubiquitin variants (UbVs) that inhibit or activate HECT E3s. UbVs unearthed distinct regulation mechanisms among NEDD4 subfamily HECTs and proved useful for modulating therapeutically relevant targets of HECT E3s in cells and intestinal organoids. [Mol Cell]
Abstract  | Graphical Abstract

Learn More: Standardized Tools for Cancer Research
Intestinal Stem Cells and Intestinal Homeostasis in Health and in Inflammation: A Review
The human intestine is a complex group of organs, highly specialized in processing food and providing nutrients to the body. It is under constant threat from microbials and toxins and has therefore developed a number of protective mechanisms. One important mechanism is the constant shedding of epithelial cells into the lumen; another is the production and maintenance of a double-layered mucous boundary in which there is continuous sampling of the luminal microbiota and a persistent presence of antimicrobial enzymes. [Surgery] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
TiGenix Announces Positive 52-Week Phase III Results of Cx601 in Complex Perianal Fistulas in Crohn’s Disease Patients
TiGenix NV announced that a single injection of Cx601 was statistically superior to placebo in achieving combined remission at week 52 in the Phase III ADMIRE-CD trial in Crohn’s disease patients with complex perianal fistulas with inadequate response to previous therapies, including antiTNFs. [TiGenix NV] Press Release

AbbVie and Boehringer Ingelheim Announce Global Collaboration on Promising Immunology Compounds
AbbVie and Boehringer Ingelheim announced a global collaboration to develop and commercialize BI 655066, an anti-IL-23 monoclonal biologic antibody in Phase III development for psoriasis. AbbVie and Boehringer Ingelheim also are evaluating the potential of this biologic therapy in Crohn’s disease, psoriatic arthritis and asthma. [Boehringer Ingelheim] Press Release

From our sponsor: Induce neural progenitor cells faster and more effectively. Watch the technical video.
National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW ICCSCE 2016 : 18th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

NEW Postdoctoral Training Fellow – Intestinal Tissue Engineering (The Francis Crick Institute)

Postdoctoral Researcher – Mechanisms of Intestinal Persistence (Institute of Food Research)

Program Director – IBD and Crohn’s Disease Program (The Leona M. and Harry B. Helmsley Charitable Trust)

Faculty Position – Cancer Research (Texas Tech University)

Postdoctoral Fellow – Nanomedicine (Johns Hopkins University)

Faculty Position – Cancer Research (Texas Tech University Health Sciences Center)

Postdoctoral Fellowship – Inflammatory Bowel Disease (Linköping University)

Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

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