Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Innovent Dosed First Participant in Phase 3 Clinical Study of IBI310 in Combination With Sintilimab for MSI-H/dMMR Colon Cancer Neoadjuvant Therapy

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the first participant has been successfully dosed with IBI310 in combination with sintilimab in a randomized, controlled, multicenter Phase III clinical trial, for resectable mismatch repair deficient colon cancer neoadjuvant therapy.

CircHAS2 Activates CCNE2 to Promote Cell Proliferation and Sensitizes the Response of Colorectal Cancer to Anlotinib

[Molecular Cancer] Investigators sought to determine the potential functions and specific mechanisms of circHAS2 in colorectal cancer progression and its role in predicting clinical response to anlotinib. CircHAS2 was a potent biomarker predictive of anlotinib sensitivity, both in patient-derived organoids and xenograft models.

Distinct Molecular Profiles Drive Multifaceted Characteristics of Colorectal Cancer Metastatic Seeds

[Journal Of Experimental Medicine] Researchers generated 10–16 single cell–derived lines from each of three colorectal cancer tumors to identify and characterize metastatic seeds. The authors discovered that intrinsic factors conferred clones with distinct metastatic potential and cellular communication capabilities, determining organ-specific metastasis.

Role of pH-Sensing Receptors in Colitis

[Pflugers Archiv-European Journal Of Physiology] The authors review the current knowledge on the role of proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer. Scientists also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.

Tumor Suppressive Role of the Epigenetic Master Regulator BRD3 in Colorectal Cancer

[Cancer Science] Scientists examined the functional role of bromodomain containing 3 (BRD3) in colorectal cancer (CRC). In vitro and in vivo analyzes using BRD3-knockdown or BRD3-overexpressing CRC cells showed that BRD3 suppressed tumor growth and cell cycle G1/S transition and induced p21 expression.

LncRNA WFDC21P Interacts with SEC63 to Promote Gastric Cancer Malignant Behaviors by Regulating Calcium Homeostasis Signaling Pathway

[Cancer Cell International] The authors investigated the biological effects and molecular mechanism of lncRNA WAP four-disulfide core domain 21 pseudogene (WFDC21P) in gastric cancer, and reported WFDC21P downregulation resulted in suppressed proliferation, tumorigenesis, migration, invasion, and promoted apoptosis in gastric cancer.

Expression of HIF1α in Intestinal Epithelium Restricts Arthritis Inflammation by Inhibiting RIPK3-Induced Cell Death Machinery

[Annals Of The Rheumatic Diseases] Researchers investigated the mechanism by which intestinal epithelial cell death induced arthritis. Effects of hypoxia-inducible factor 1α (HIF1α) stabilization by inhibition of prolyl hydroxylase domain-containing enzymes and treatment with the inhibitor of receptor-interacting protein kinase-3 (RIPK3) were tested in intestinal organoids and in collagen-induced arthritis.

Notoginsenoside R1 Promotes Lgr5+ Stem Cell and Epithelium Renovation in Colitis Mice via Activating Wnt/β-Catenin Signaling

[Acta Pharmacologica Sinica] The authors investigated the reparative effects of notoginsenoside R1 (NGR1) on mucosal barrier damage after the acute injury stage of DSS exposure. NGR1 (100 μM) also increased Lgr5+ cells and budding rates in a 3D intestinal organoid model. They demonstrated that NGR1 promoted intestinal stem cell proliferation and differentiation through activation of the Wnt signaling pathway.

Colorectal Cancer Cells Secreting DKK4 Transform Fibroblasts To Promote Tumour Metastasis

[Oncogene] Scientists showed that a soluble extracellular inhibitor of Wnt/β-catenin signaling, dickkopf‐related protein 4 (DKK4), was an independent factor for poor outcomes in colorectal cancer patients.

The EIF3H-HAX1 Axis Increases RAF-MEK-ERK Signaling Activity To Promote Colorectal Cancer Progression

[Nature Communications] Investigators reported that eukaryotic initiation translation factor 3 subunit h (EIF3H) was overexpressed in colorectal cancer and correlated with poor prognosis.

Platinum Iodido Drugs Show Potential Anti-Tumor Activity, Affecting Cancer Cell Metabolism and Inducing ROS and Senescence in Gastrointestinal Cancer Cells

[Communications Biology] Researchers studied the mechanism of action of the isomers trans and cis-[PtI2(isopropylamine)2] against gastrointestinal cancer cells.

The Alanyl-tRNA Synthetase AARS1 Moonlights as a Lactyl-Transferase To Promote YAP Signaling in Gastric Cancer

[Journal Of Clinical Investigation] Alanyl-tRNA synthetase 1 (AARS1) was identified as a Hippo target gene that formed a positive feedback loop with YAP-TEAD to promote gastric cancer cell proliferation.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.

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