Volume 2.05 | Feb 12

Intestinal Cell News 2.05 February 12, 2016
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Visualization of a Short-Range Wnt Gradient in the Intestinal Stem-Cell Niche
Scientists generated an epitope-tagged, functional Wnt3 knock-in allele. In intestinal organoids, Wnt3-transfer involved direct contact between Paneth cells and stem cells. [Nature] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

Deletion of Men1 and Somatostatin Induces Hypergastrinemia and Gastric Carcinoids
Researchers defined the genetic background that creates a permissive environment for gastric carcinoids using transgenic mouse lines. The combination of conditional multiple endocrine neoplasia 1 gene locus (Men1) deletion in the absence of somatostatin led to the development of gastric carcinoids within two years. [Gut] Abstract

A Network-Based Analysis of Colon Cancer Splicing Changes Reveals a Tumorigenesis-Favoring Regulatory Pathway Emanating from ELK1
Scientists revealed a novel tumor-favoring regulatory pathway involving the induction of the transcription factor MYC by the transcription factor ELK1, and the subsequent induction of the alternative splicing factor PTBP1 by both. [Genome Res] Abstract

Cell Competition Drives the Growth of Intestinal Adenomas in Drosophila
Investigators used the adult fly intestine to investigate the existence and characterize the role of competitive tumor-host interactions. They showed that APC-/-driven intestinal adenomas compete with and kill surrounding cells, causing host tissue attrition. [Curr Biol] Full Article | Graphical Abstract | Press Release

14-3-3 Proteins Regulate Akt Thr308 Phosphorylation in Intestinal Epithelial Cells
The authors report that 14-3-3 proteins control Akt Thr308 phosphorylation during intestinal inflammation. They found that IFNγ and TNFα treatment induce degradation of the phosphoinositide-dependent kinase 1 inhibitor, 14-3-3η, in intestinal epithelial cells. [Cell Death Differ] Abstract

AIM2 Contributes to the Maintenance of Intestinal Integrity via Akt and Protects against Salmonella Mucosal Infection
Researchers demonstrated that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. [Mucosal Immunol] Abstract

Inhibition of NF-κB Translocation by Curcumin Analogs Induces G0/G1 Arrest and Downregulates Thymidylate Synthase in Colorectal Cancer
Scientists tested the hypothesis that inhibition of NF-κB translocation by curcumin and its analogs EF31 and UBS109 can inhibit cell cycle progression and downregulate thymidylate synthase levels in colorectal cancer cell lines. [Cancer Lett] Abstract

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway
Researchers demonstrated that KCTD12, potassium channel tetramerization domain containing 12, is down-regulated in the cancer stem cell-like cells of colorectal cancer. [Sci Rep] Full Article

Hepatocyte Nuclear Factor 1 Coordinates Multiple Processes in a Model of Intestinal Epithelial Cell Function
The authors investigated the transcriptional network governed by hepatocyte nuclear factor 1 (HNF1) in an intestinal epithelial cell line. Gene ontology process enrichment analysis of the HNF1 targets identified multiple processes with a role in intestinal epithelial cell function, including properties of the cell membrane, cellular response to hormones, and regulation of biosynthetic processes. [Biochim Biophys Acta] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Selective and Reversible Suppression of Intestinal Stem Cell Differentiation by Pharmacological Inhibition of BET Bromodomains
Investigators demonstrated that mice treated with a small molecule inhibitor of BET bromodomains, CPI203, exhibit greater than 90% decrease in tuft and enteroendocrine cells in both crypts and villi of the small intestine, with no changes observed in goblet or Paneth cells. [Sci Rep] Full Article

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REVIEWS
Notch Regulation of Gastrointestinal Stem Cells
The authors summarize the literature regarding Notch regulation of gastrointestinal stem cell proliferation and differentiation, highlighting tissue specific functions to compare and contrast Notch in the stomach and intestine. [J Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
 
INDUSTRY NEWS
Atlantic Healthcare Starts Pivotal Phase III Trial of Alicaforsen to Treat Inflammatory Bowel Disease Pouchitis
Atlantic Healthcare plc announced that patient recruitment has commenced for a Phase III trial of its wholly-owned product alicaforsen enema to treat inflammatory bowel disease pouchitis. [Atlantic Healthcare plc] Press Release

Synlogic Announces First Industry Collaboration to Develop a New Class of Medicines Designed to Power the Microbiome
Synlogic announced the signing of a multi-year global R&D collaboration with AbbVie. The collaboration is focused on developing novel medicines for the treatment of inflammatory bowel disease using Synlogic’s proprietary approach for a new class of synthetic biotic medicines that power the microbiome. [Synlogic] Press Release

Fast Forward Pharmaceuticals Initiates Phase II Pilot Studies in Primary Biliary Cirrhosis and Crohn’s Disease with Anti-CD40 Monoclonal Antibody
Fast Forward Pharmaceuticals BV announced that following the successful completion of a Phase I study in healthy volunteers it has initiated two Phase II clinical trials in primary biliary cirrhosis and Crohn’s disease with its lead product FFP104. [Fast Forward Pharmaceuticals BV] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Gordon Research Conference – Notch Signaling in Development, Regeneration & Disease
July 31-August 5, 2016
Lewiston, United States

Visit our events page to see a complete list of events in the intestinal cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellowship – Inflammatory Bowel Disease (Linköping University)

Postdoctoral Researcher – Cancer Epigenetics (University of Pennsylvania)

Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

Research Associate – Autoimmunity (The Scripps Research Institute)

Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

Gastroenterologist – Inflammatory Bowel Disease (Mayo Clinic)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

Faculty Position – Gastrointestinal Physiology (University of Ottawa)

PhD Studentship – Cell Biology (Cologne Graduate School of Ageing Research)

Postdoctoral Position – Gut Inflammation and IBD (University College Cork)


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