Volume 2.04 | Feb 5

Intestinal Cell News 2.04 February 5, 2016
Intestinal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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How Gut Inflammation Sparks Colon Cancer
Researchers focused on a microRNA called miR-34a that gives cancer stem cells the odd ability to divide asymmetrically. They concluded that even though miR-34a is active in cancer, it’s actually a good guy. Triggered to act when the gut becomes inflamed, miR-34a forces the process of asymmetrical division, helping to control normal stem cell populations. [Press release from Duke University discussing online prepublication in Cell Stem Cell] Press Article | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet
Scientists demonstrated that the LXR-responsive phospholipid-remodeling enzyme Lpcat3 modulates intestinal fatty acid and cholesterol absorption and is required for survival on a high-fat diet. [Cell Metab]
Abstract | Graphical Abstract

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer
The authors report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation, modulates inflammation and inflammation-associated cancer in mice and humans. [Cell Rep] Full Article | Graphical Abstract

IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
The authors identified a small subpopulation of NANOG-positive colorectal cancer cells, and demonstrated that they exhibited characteristics of cancer stem cells and epithelial-mesenchymal transition traits simultaneously. [Stem Cells] Abstract

Role of CD44high/CD133high HCT-116 Cells in the Tumorigenesis of Colon Cancer
Scientists aimed to explore cell surface biomarkers related to cancer stem cells and their role in the tumorigenesis of colon cancer. [Oncotarget] Full Article

miR-143 or miR-145 Overexpression Increases Cetuximab-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Colon Cancer Cells
miR-143 and miR-145 are downregulated in colon cancer. Researchers tested the effect of restoring these miRNAs on sensitization to cetuximab in mutant KRAS and wild-type KRAS colon cancer cells. [Oncotarget] Full Article

Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress
Researchers report that mutant KRAS colon cancer cells are more susceptible to apoptosis induced by the heat shock protein 90 inhibitor AUY922 than those carrying wild-type KRAS. [Mol Cancer Ther] Abstract

Epigenetic Regulation of E-Cadherin Expression by the Histone Demethylase UTX in Colon Cancer Cells
Investigators identified ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase involved in demethylating di- or tri-methylated histone 3 lysine 27, as a positive regulator for the expression of E-cadherin in the colon cancer cell line HCT-116. [Med Oncol] Abstract


Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries
Investigators utilized the Drosophila midgut, a powerful model for intestinal stem cell regulation, to elucidate the mechanisms by which Wingless/Wnt regulates intestinal homeostasis and development. [PLoS Genet] Full Article

Wildtype Adult Stem Cells, unlike Tumor Cells, Are Resistant to Cellular Damages in Drosophila
Scientists found that in the adult Drosophila midgut, intestinal stem cells (ISCs), unlike tumor intestinal cells, are resistant to various cellular damages. Tumor intestinal cells, unlike wildtype ISCs, were easily eliminated by apoptosis. [Dev Biol] Abstract

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Plasticity of the Brush Border — the Yin and Yang of Intestinal Homeostasis
The authors review the processes and components involved in brush border organization and discuss pathological mechanisms that can induce brush border defects and their physiological consequences. [Nat Rev Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Data on Immunology Effects of Provectus Biopharmaceuticals PV-10 in Colon Cancer Presented
Provectus Biopharmaceuticals, Inc. announced data discussing the immunologic effects of PV-10 on colon cancer cells were presented. [Press release from Provectus Biopharmaceuticals, Inc. discussing research presented at the 11th Annual Academic Surgical Congress, Jacksonville] Press Release

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NUI Galway Launch €6 Million Robotic Stem Cell Production Project
NUI Galway’s Regenerative Medicine Institute has launched a new €6 million research project AUTOSTEM to develop pioneering manufacturing systems for stem cell therapy. Funded by the EU Horizon 2020 program, AUTOSTEM will go a long way towards meeting the demand for these new treatments, by transforming the way stem cells are manufactured. [National University of Ireland, Galway] Press Release

New Jersey Health Foundation Awards $1 Million to Advance Research throughout NJ
New Jersey Health Foundation has awarded 30 grants totaling more than $1 million for researchers in New Jersey who are working on health-related research that demonstrates exciting potential. [New Jersey Health Foundation (PR Newswire Association LLC.)] Press Release

Spectrum Awards More than $1 Million in Pilot Grants to 30 Projects
Thirty biomedical projects at Stanford have received a total of $1.1 million in research funding through the Spectrum pilot grant program. [Stanford School of Medicine] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 24th Biennial European Association for Cancer Research (EACR) Congress
July 9-16, 2016
Manchester, United Kingdom

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Researcher – Cancer Epigenetics (University of Pennsylvania)

NEW Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

NEW Research Associate – Autoimmunity (The Scripps Research Institute)

NEW Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

NEW Gastroenterologist – Inflammatory Bowel Disease (Mayo Clinic)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

Faculty Position – Gastrointestinal Physiology (University of Ottawa)

PhD Studentship – Cell Biology (Cologne Graduate School of Ageing Research)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Postdoctoral Position – Gut Inflammation and IBD (University College Cork)

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