Volume 1.39 | Dec 18

Newsletter Issue
Intestinal Cell News 1.39 December 18, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Tuft-Cell-Derived IL-25 Regulates an Intestinal ILC2–Epithelial Response Circuit
Scientists showed that tuft cells constitutively express interleukin (IL)-25 to sustain tissue-resident group 2 innate lymphoid cells (ILC2) homeostasis in the resting lamina propria in mice. After helminth infection, tuft-cell-derived IL-25 further activated ILC2s to secrete IL-13, which acts on epithelial crypt progenitors to promote differentiation of tuft and goblet cells, leading to increased frequencies of both. [Nature] Abstract
PUBLICATIONS (Ranked by impact factor of the journal)

Contributions of Microbiome and Mechanical Deformation to Intestinal Bacterial Overgrowth and Inflammation in a Human Gut-on-a-Chip
A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a week in vitro and to analyze how gut microbiome, inflammatory cells, and peristalsis-associated mechanical deformations independently contribute to intestinal bacterial overgrowth and inflammation. [Proc Natl Acad Sci USA] Abstract | Press Release

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis
Scientists demonstrated that aberrant expression of ubiquitin specific protease 4 (USP4) contributes to the development and progression of colorectal cancer and revealed a critical mechanism underlying USP4-mediated oncogenic activity. [Cancer Res] Abstract

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins
Investigators demonstrated that MSI1 and MSI2 act as functionally redundant oncoproteins required for the ontogeny of intestinal cancers. [Cell Rep] Full Article | Graphical Abstract

Combination of Tolfenamic Acid and Curcumin Induces Colon Cancer Cell Growth Inhibition by Modulating Reactive Oxygen Species and Specific Transcription Factors
Researchers investigated the therapeutic efficacy of curcumin in combination with the small molecule tolfenamic acid in colorectal cancer cell lines. [Oncotarget] Full Article

Network-Level Effects of Kinase Inhibitors Modulate TNF-α-Induced Apoptosis in the Intestinal Epithelium
Researchers found that inhibitors of the mitogen-activated protein kinase kinase kinase Raf, MEK, or extracellular signal-regulated kinase exerted distinct effects on the timing and magnitude of tumor necrosis factor-α (TNF-α)-induced apoptosis in the mouse intestine. [Sci Signal] Abstract

Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome
The authors used stable isotope labeling by amino acids in cell culture and affinity enrichment followed by high-resolution liquid chromatograph-mass spectrometer (LC-MS)/MS analysis to quantitate the changes in the lysine acetylome in HCT-8 cells after FK228 treatment. [Sci Rep] Full Article

A Simple Coculture System Shows Mutualism between Anaerobic Faecalibacteria and Epithelial Caco-2 Cells
Researchers describe the development of a coculture system for intestinal Caco-2 cells and an anaerobic symbiont, Faecalibacterium prausnitzii. [Sci Rep] Full Article


HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Researchers identified HOXA5 as an important repressor of intestinal stem cell fate in vivo and identified a reciprocal feedback between HOXA5 and Wnt signaling. [Cancer Cell]
Abstract | Graphical Abstract | Press Release

Hindsight/RREB-1 Functions in Both the Specification and Differentiation of Stem Cells in the Adult Midgut of Drosophila
Investigators showed that hindsight is required for enterocyte (EC) differentiation in the context of intestinal stem cells-to-enteroblast differentiation, but not in the context of adult midgut precursor-to-EC differentiation. [Biol Open] Full Article

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology
Primary cultures developed from isolated intestinal crypts or stem cells and from inducible pluripotent stem cells are being applied to study human intestinal physiology and pathophysiology with great expectations for translational applications, including regenerative medicine. The authors discuss the physiologic properties of these cultures, their current use in understanding diarrhea-causing host-pathogen interactions, and potential future applications. [J Biol Chem] Abstract | Full Article

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Agendia and Partners Receive $6.8 Million from European Commission to Study Targeted Therapies for Colorectal Cancer
Agendia, Inc. and several European partners have received a $6.8 million European Commission grant to study targeted therapies for colorectal cancer. [Agendia, Inc.] Press Release

Galapagos and Gilead Announce Global Partnership to Develop Filgotinib for the Treatment of Rheumatoid Arthritis and Other Inflammatory Diseases
Galapagos NV and Gilead Sciences, Inc. announced that the companies have entered into a global partnership for the development and commercialization of the JAK1-selective inhibitor filgotinib for inflammatory disease indications. [Galapagos NV] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

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NEW Stem Cell Production Scientist (Definigen Ltd)

PhD Student – Colorectal/Pancreatic Cancer (German Cancer Research Center)

Postdoctoral Fellow – Cancer Immunotherapy (Inserm)

Postdoctoral Scientist – Gastroenterology and Immunology (University of Oxford)

Research Associate – Immunology and Inflammation (Imperial College London)

Research Technician – Preclinical and Translational Research (Qu Biologics Inc.)

Faculty Position – Autoimmune Disease and Rheumatologic Inflammation (Cleveland Clinic)

Computational Postdoctoral Associate – Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Postdoctoral Associate – Epigenetics of Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Open Group Leader Position – Cancer Research (Oslo University Hospital)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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