Volume 1.37 | Dec 4

Intestinal Cell News 1.37 December 4, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Intracellular Calcium Integrates Complex Signaling to Control Stem Cell Activity
Researchers have identified a new mode of stem cell regulation. Working in the fly gut, they showed that stem cells adjust their proliferative activity in response to a wide variety of signals via intracellular calcium signaling. [Press release from the Buck Institute discussing online prepublication in Nature] Press Release | Abstract
Free wallchart: The Intestinal Crypt
 
PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Investigators showed that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells conferred protection from colitis and mucosal damage in mice. [Cell] Abstract | Graphical Abstract | Press Release

IKKβ Acts as a Tumor Suppressor in Cancer-Associated Fibroblasts during Intestinal Tumorigenesis
Using an autochthonous model of colitis-associated cancer and sporadic cancer, scientists provide evidence for a tumor-suppressive function of IKKβ/NF-κB in cancer-associated fibroblasts. [J Exp Med] Abstract

Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer
Researchers investigated the consequences of conditionally ablating p53 in the highly relevant Lgr5+ stem cell population on tumor initiation and progression in the colon. [Cancer Res] Abstract

ML264 – A Novel Small-Molecule Compound that Potently Inhibits Growth of Colorectal Cancer
Scientists showed that a novel small molecule targeting KLF5 expression, ML264, potently inhibits proliferation of colorectal cancer cells in vitro through modifications of the cell cycle profile. [Mol Cancer Ther] Abstract

TET-Catalyzed 5-Hydroxymethylcytosine Regulates Gene Expression in Differentiating Colonocytes and Colon Cancer
The authors showed that 5-hydroxymethylcytosine regulates gene expression during colonocyte differentiation and controls gene expression in human colon cancers. [Sci Rep] Full Article

Inhibition of PhospholipaseD2 Increases Hypoxia-Induced Human Colon Cancer Cell Apoptosis through Inactivating of the PI3K/AKT Signaling Pathway
Investigators observed significantly elevated phospholipase D2 (PLD2) and survivin expression levels in colon cancer tissues and cells. They found that hypoxia induced the activity of PLD increased significant mainly caused by PLD2 in colon cancer cells. [Tumor Biol] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

mTOR Disruption Causes Intestinal Epithelial Cell Defects and Intestinal Atrophy Postinjury in Mice
The authors report that mechanistic target of rapamycin (mTOR) supports absorptive enterocytes and secretory Paneth and goblet cell function while negatively regulating chromogranin A-positive enteroendocrine cell number. [FASEB J] Abstract

Mesenchymal Stem Cells Can Delay Radiation-Induced Crypt Death: Impact on Intestinal CD44+ Fragments
Scientists identified and isolated intestinal stem cells from C57BL/6 mice by using a cell surface antigen, CD44. In vitro, some CD44+ crypt cells were capable of forming “villus-crypt”–like structures (organoids). They investigated the specific roles of mesenchymal stem cells in protecting organoids against radiation-induced crypt death. [Cell Tissue Res] Full Article

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REVIEWS
Immunopathogenesis of IBD: Current State of the Art
The authors review current knowledge of the classic immune components and will expand the concept of IBD immunopathogenesis to include various cells, mediators and pathways that have not been traditionally associated with disease mechanisms, but that profoundly affect the overall intestinal inflammatory process. [Nat Rev Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the Intestinal Cell research field.
 
INDUSTRY NEWS
TxCell Signs Strategic Agreement with MaSTherCell for European Manufacturing of Its Cell Therapy Products
TxCell SA announced it has signed a five-year agreement with MaSTherCell. TxCell already appointed MaSTherCell for the manufacturing of TxCell’s lead product Ovasave® for the ongoing CATS29 study. CATS29 is a Phase IIb trial of Ovasave conducted in refractory Crohn’s diseases patients. [TxCell SA] Press Release

MassGeneral Hospital for Children Receives Grant to Pursue Novel Antibacterial Strategy
MassGeneral Hospital for Children has been named a Grand Challenges Explorations winner through an initiative funded by the Bill & Melinda Gates Foundation. Researchers will pursue an innovative global health and development research project, titled “Disarming Type III Secretion System of Enteric Pathogens.” [MassGeneral Hospital (EurekAlert!)] Press Release

Ignyta and EORTC Announce Entrectinib as 1st Investigational Cancer Agent in EORTC SPECTA
Ignyta, Inc. and the European Organisation for Research and Treatment of Cancer (EORTC) announced that they will collaborate via EORTC’s Screening Patients for Efficient Clinical Trial Access (SPECTA) biomarker screening initiative to identify patients who harbor a gene rearrangement to NTRK1, NTRK3, ROS1 or ALK and therefore may be eligible for Ignyta’s global STARTRK-2 Phase II clinical study. [European Organisation for Research and Treatment of Cancer] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells and Organoids as Models of Tissue Differentiation and Disease
January 12, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the Intestinal Cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Scientist – Gastroenterology and Immunology (University of Oxford)

NEW Postdoctoral Fellow – Gastrointestinal Cancer (Fred Hutchinson Cancer Research Center)

Research Associate – Immunology and Inflammation (Imperial College London)

Research Technician – Preclinical and Translational Research (Qu Biologics Inc.)

Faculty Position – Autoimmune Disease and Rheumatologic Inflammation (Cleveland Clinic)

Postdoctoral Fellowship – Innate Lymphoid Cell-Epithelial Cell Interactions in Intestinal Lymphoid Follicles (Linköping University)

Computational Postdoctoral Associate – Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Postdoctoral Associate – Epigenetics of Inflammatory Bowel Disease (Icahn School of Medicine at Mount Sinai)

Open Group Leader Position – Cancer Research (Oslo University Hospital)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)


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