Volume 1.32 | Oct 30

Intestinal Cell News 1.32 October 30, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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Lab-Developed Intestinal Organoids Form Mature Human Tissue in Mice
Researchers have successfully transplanted “organoids” of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice – creating an unprecedented model for studying diseases of the intestine. [Press release from Cincinnati Children’s Hospital discussing online prepublication in Nature Medicine] Press Release | Abstract
Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
PUBLICATIONS (Ranked by impact factor of the journal)

Long Non-Coding RNA ZFAS1 Interacts with CDK1 and Is Involved in p53-Dependent Cell Cycle Control and Apoptosis in Colorectal Cancer
The authors showed that ZFAS1 silencing decreases proliferation through G1-arrest of cell cycle, and also tumorigenicity of colorectal cancer cells. [Oncotarget] Full Article

Bis-Cyclopropane Analog of Disorazole C1 Is a Microtubule-Destabilizing Agent Active in ABCB1-Overexpressing Human Colon Cancer Cells
The novel, chemically stabilized disorazole analog, (-)-CP2-disorazole C1 displayed potent anti-proliferative activity against a broad-spectrum of human colorectal cancer cells. [Oncotarget] Full Article

The Effects of a Novel Aliphatic-Chain Hydroxamate Derivative WMJ-S-001 in HCT116 Colorectal Cancer Cell Death
Researchers explored the underlying mechanisms by which WMJ-S-001 induces HCT116 colorectal cancer cell death. [Sci Rep] Full Article

Effect of Heat-Inactivated Clostridium sporogenes and Its Conditioned Media on 3-Dimensional Colorectal Cancer Cell Models
The effects of heat-inactivated C. sporogenes bacteria and conditioned media on CT26 and HCT116 colorectal cancer cells were examined on a 2-dimensional and 3-dimensional platform. [Sci Rep] Full Article

Oncogenic Activin C Interacts with Decorin in Colorectal Cancer In Vivo and In Vitro
The authors found that the expression of activin C was remarkably increased in the intestine of Dcn-/- mice compared to the expression of activin C in the intestine of Dcn+/+ mice. Addition of activin C protein to colorectal cancer cells or over-expression of activin C in these cells stimulated cell growth, migration, and invasion in vitro. [Mol Carcinog] Abstract

LncRNA-ATB Mediated E-Cadherin Repression Promotes the Progression of Colon Cancer and Predicts Poor Prognosis
Researchers elucidated the role of long non-coding RNA-activated by TGF-β (lncRNA-ATB) and its clinical value in colon cancer. [J Gastroenterol Hepatol] Abstract

MiR-320b Suppresses Cell Proliferation by Targeting C-Myc in Human Colorectal Cancer Cells
Investigators showed that miR-320b expression was down regulated in both colorectal cancer (CRC) tissues and cells. Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo, while c-MYC was identified as a target gene of miR-320b in CRC. [BMC Cancer] Full Article


Comparative Effects of Diet and Carcinogen on MicroRNA Expression in the Stem Cell Niche of the Mouse Colonic Crypt
The authors utilized Lgr5+ reporter mice to determine the impact of diet and carcinogen on miRNA expression in colonic stem cells and their progeny. [Biochim Biophys Acta] Abstract

Register Now: Intestinal Organoid Workshop in Cambridge
Cell Death at the Intestinal Epithelial Front Line
The authors discuss cell death processes in the intestinal epithelium in health and disease, with special emphasis on TNF receptor family-triggered cell death. [FEBS J] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Phase II Maintenance Data from Oral Ozanimod TOUCHSTONE Study in Ulcerative Colitis Presented at UEG Week
Celgene International Sàrl presented results from the maintenance phase of the TOUCHSTONE Phase II clinical trial of Ozanimod, an investigational compound, in patients with moderate to severe ulcerative colitis. [Press release from Celgene Corporation discussing research presented at the United European Gastroenterology (UEG) Week, Barcelona] Press Release

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MacroGenics and Merck to Collaborate on Immuno-Oncology Study Evaluating Margetuximab in Combination with KEYTRUDA® (Pembrolizumab) for Advanced Gastric Cancer
MacroGenics, Inc. and Merck announced a collaboration to evaluate the combination of MacroGenics’ anti-HER2 product candidate, margetuximab, with Merck’s anti-PD-1 therapy, KEYTRUDA®, in a Phase Ib/II clinical trial in patients with advanced gastric cancer. [MacroGenics, Inc.] Press Release

$20 Million Commonwealth Foundation for Cancer Research Gift to Expand Collaborative Cancer Research
The Commonwealth Foundation for Cancer Research has pledged $20 million to the Bridge Project, a collaborative research program of the Koch Institute for Integrative Cancer Research at MIT and the Dana-Farber/Harvard Cancer Center, to accelerate the translation of interdisciplinary cancer solutions toward the clinic. [Massachusetts Institute of Technology] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW German Cancer Congress 2016
February 24-27, 2016
Berlin, Germany

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

Postdoctoral Scientist – Cancer Biology, Immunology and Gastrointestinal Research (Cedars-Sinai)

Project Manager – Manufacturing (Qu Biologics)

Postdoctoral Research Fellow/Research Scientist – Biotechnology (Qu Biologics)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

PhD Positions – Gut Microbiota and Colon Cancer (University of Southern Denmark)

Postdoctoral Research Fellow – Colorectal Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

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