Volume 1.29 | Oct 9

Intestinal Cell News 1.29 October 9, 2015
Intestinal Cell News
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Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
Scientists provided evidence for interleukin-17A (IL-17A)-dependent regulation of the tight junction protein occludin during epithelial injury that limits excessive permeability and maintains barrier integrity. Analysis of epithelial cells showed that in the absence of signaling via the IL-17 receptor adaptor protein Act-1, the protective effect of IL-17A was abrogated and inflammation was enhanced. [Immunity] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells from Patients with Crohn’s Disease
Researchers investigated the profile of polyunsaturated fatty acid metabolites produced by enteric glial cells from rats and from patients with Crohn’s disease, compared with controls, along with the ability of one of these metabolites, 15-hydroxyeicosatetraenoic acid (15-HETE), to regulate the permeability of the intestinal epithelial barrier. [Gastroenterology] Abstract

Atypical Role of Sprouty in Colorectal Cancer: Sprouty Repression Inhibits Epithelial–Mesenchymal Transition
Scientists investigated the mechanisms by which Sprouty regulates epithelial–mesenchymal transition in colorectal cancer. [Oncogene] Full Article

Tumor-Selective Proteotoxicity of Verteporfin Inhibits Colon Cancer Progression Independently of YAP1
The authors found that verteporfin inhibited tumor growth independently of its effects on Yes-associated protein 1 (YAP1) or the related protein TAZ in genetically or chemically induced mouse models of colorectal cancer (CRC), in patient-derived xenografts, and in enteroid models of CRC. [Sci Signal] Abstract

Epigenetic Changes and Alternate Promoter Usage by Human Colon Cancers for Expressing DCLK1-Isoforms: Clinical Implications
The authors report that the majority of human colon adenocarcinomas express short-transcripts of DCLK1 from an alternate β-promoter in IntronV of the gene, while normal-colons mainly express DCLK1-L from 5′(α)-promoter. [Sci Rep] Full Article

GPR55 Promotes Migration and Adhesion of Colon Cancer Cells Indicating a Role in Metastasis
Scientists investigated the involvement of G protein-coupled receptor 55 (GPR55) in migration and metastasis of colon cancer cells. [Br J Pharmacol] Abstract

Mechanisms of DRA Recycling in Intestinal Epithelial Cells: Effect of Enteropathogenic E. Coli
The authors investigated SLC26A3 (DRA) trafficking under basal conditions and in response to EPEC utilizing Caco-2 cells. [Am J Physiol Cell Physiol] Abstract

Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice
Researchers studied the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells and on mice tissues to decipher the underlying mechanisms. [PLoS One] Full Article

Esculetin Induces Apoptosis in Human Colon Cancer Cells by Inducing Endoplasmic Reticulum Stress
Investigators examined whether esculetin induces apoptosis in HT-29 colon cancer cells by inducing endoplasmic reticulum (ER) stress. They found that esculetin induced characteristic signs of ER stress, confirmed by ER staining, mitochondrial calcium overload and expression of ER stress-related proteins. [Cell Biochem Funct] Abstract


Rapamycin Preserves Gut Homeostasis during Drosophila Aging
Researchers demonstrated that rapamycin can slow down the proliferation rate of intestinal stem cells in the aging guts and induce autophagy in the intestinal epithelium in Drosophila. [Oncotarget] Full Article

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Mini-Gut Organoids: Reconstitution of Stem Cell Niche
The mini-gut organoid culture platform is applicable to various types of digestive tissue epithelium from multiple species. The mechanism of self-renewal in organoids provides novel insights for organogenesis, regenerative medicine, and tumorigenesis of the digestive system. [Annu Rev Cell Dev Biol] Abstract

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Nektar Submits Investigational New Drug Application (IND) for NKTR-214 to Treat Solid Tumor Malignancies
Nektar Therapeutics announced that it has submitted an investigational new drug application to the U.S. Food and Drug Administration for NKTR-214, its lead immuno-oncology candidate. [Nektar Therapeutics] Press Release

Synthetic Biologics Initiates Second SYN-010 Phase II Clinical Trial Intended to Treat Irritable Bowel Syndrome with Constipation (IBS-C)
Synthetic Biologics, Inc. reported the initiation of the second Phase II clinical trial of its proprietary SYN-010 for the treatment of irritable bowel syndrome with constipation. [Synthetic Biologics, Inc.] Press Release

Positive Phase III Top Line Results Demonstrate Efficacy of NER1006, a Novel, Low Volume Bowel Preparation, vs. Trisulfate
Norgine announced positive top line results for its Phase III study, NOCT, a multicenter, randomized, parallel-group clinical trial comparing the bowel cleansing efficacy of a two-day split-dosing regimen of NER1006, versus a split-dosing regimen of a trisulfate bowel cleansing solution (SUPREP®) in adult patients undergoing screening, surveillance or diagnostic colonoscopy. [Norgine B.V.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Intestinal Stem Cells: Current Views & Future Perspectives
November 5, 2015
Nantes, France

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NEW Project Manager – Manufacturing (Qu Biologics)

NEW Postdoctoral Research Fellow/Research Scientist – Biotechnology (Qu Biologics)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Inflammation (Amgen)

Postdoctoral Fellow – Investigation of Intestinal Epithelial Integrity with Organoid Cultures (AbbVie Inc.)

PhD Positions – Gut Microbiota and Colon Cancer (University of Southern Denmark)

Senior Stem Cell Scientist (Medicines and Healthcare Products Regulatory Agency)

Postdoctoral Researcher – Immunology (University of Oxford)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Research Fellow – Colorectal Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

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