Volume 1.25 | Sep 11

Intestinal Cell News 1.25 September 11, 2015
Intestinal Cell News
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The E3 Ligase RNF43 Inhibits Wnt Signaling Downstream of Mutated β-Catenin by Sequestering TCF4 to the Nuclear Membrane
Scientists detected endogenous RNF43 in the nucleus of human intestinal crypt and colon cancer cells. They found that RNF43 physically interacted with T cell factor 4 (TCF4) in cells and tethered TCF4 to the nuclear membrane, thus silencing TCF4 transcriptional activity even in the presence of constitutively active mutants of β-catenin. [Sci Signal] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Expression of Tumor-Related Rac1b Antagonizes B-Raf-Induced Senescence in Colorectal Cells
The authors used normal NCM460 colonocytes as a model to express oncogenic B-Raf-V600E in the presence or absence of co-transfected Rac1b and then analyzed the effect on expression of senescence markers. [Cancer Lett] Abstract

DNA Methyltransferase 3A Promotes Cell Proliferation by Silencing CDK Inhibitor p18INK4C in Gastric Carcinogenesis
Researchers reported that the exogenous expression of DNA methyltransferase 3A promoted gastric cancer cell proliferation by accelerating the G1/S transition. [Sci Rep] Full Article

Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway
Corticotropin-releasing hormone (CRH) and urocortin 3 significantly increased the expression levels of vascular endothelial growth factor-A mRNA and protein through CRH receptor 1 and 2 respectively in human colonic epithelial cells and primary mouse intestinal epithelial cells. [J Biol Chem] Abstract | Full Article

Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway
AGO2 expression was assessed in epithelial and immune cells, and intestinal organoids with disrupted autophagy. Increased AGO2 was also detected in ATG7-/- intestinal organoids, in comparison with wild-type organoids. [Inflamm Bowel Dis] Abstract

L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells
The authors tested the hypothesis that L-Glutamate may enhance the barrier function of intestinal porcine epithelial cell line 1 cells by upregulating the expression of tight junction proteins. [J Nutr] Abstract

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase
Scientists revealed a previously unappreciated role for G. duodenalis cathepsin cysteine proteases in intestinal epithelial pathophysiological processes that occur during giardiasis. [PLoS One] Full Article

HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5
Scientists showed that lysophosphatidic acid (LPA) transcriptionally regulates migration inhibitory factor (MIF) expression in colon cancer cells. MIF knockdown decreased LPA-mediated proliferation of HCT116 human adenocarcinoma cells without altering the basal proliferation rates. [PLoS One] Full Article

Mitochondrial Metabolism in Cancer Stem Cells: A Therapeutic Target for Colon Cancer
Researchers found that forkhead box protein 1 (FOXM1)-induced peroxiredoxin 3 (PRDX3) maintained mitochondrial function, and the FOXM1/PRDX3 mitochondrial pathway maintains survival of colon cancer stem cells. [BMB Rep] Abstract | Download Full Article

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Emerging Cytokine Networks in Colorectal Cancer
The authors discuss how cancer mutations and epigenetic adaptations influence the oncogenic potential of cytokines, a relatively unexplored area that could yield crucial insights into tumour immunology and facilitate the effective application of cytokine-modulatory therapies for colorectal cancer. [Nat Rev Immunol] Abstract

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BioLife Solutions Customer TiGenix Phase III Clinical Trial Meets Primary Endpoint
BioLife Solutions, Inc. announced that its customer TiGenix N recently disclosed that its lead compound Cx601 met the primary endpoint in the Phase III ADMIRE-CD trial of complex perianal fistula in Crohn’s disease patients. [BioLife Solutions, Inc.] Press Release

Five Prime Therapeutics Initiates Patient Dosing in Phase Ia/Ib Trial Evaluating the Immunotherapy Combination of FPA008 and OPDIVO (Nivolumab) in Six Tumor Types
Five Prime Therapeutics, Inc. announced that it has initiated patient dosing in the Phase Ia/Ib clinical trial evaluating the immunotherapy combination of FPA008, Five Prime’s monoclonal antibody that inhibits colony stimulating factor-1 receptor with OPDIVO®, Bristol-Myers Squibb’s PD-1 immune checkpoint inhibitor, in six tumor types. [Five Prime Therapeutics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposia: Stem Cells and Regeneration in the Digestive Organs
March 13-17, 2016
Keystone, United States

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NEW Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Colorectal Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Drug Discovery and Action (University of Illinois)

Postdoctoral or PhD position – Intestinal Lipidomics (Max Planck Institute of Molecular Cell Biology and Genetics)

Senior Research Technician (Qu Biologics Inc.)

Genetic Counselor – Cancer (Fred Hutchinson Cancer Research Center)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

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