Volume 1.22 | Aug 21

Intestinal Cell News 1.22 August 21, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Dutch scientists develop method for identifying rare cells
RaceID was used to analyze cultured mini-intestines (organoids). In these organoids, scientists discovered a new subpopulation of hormone producing intestinal cells. These so called enteroendocrine cells are important for gut homeostasis and are therefore crucial for the digestive function of the intestine. [Press release from Hubrecht Institute discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

Apolipoprotein A-I Inhibits Experimental Colitis and Colitis-Propelled Carcinogenesis
Researchers report intrinsic differences in gene expression between proximal and distal colon in the mouse, which are augmented during dextran sodium sulfate/azoxymethane-induced colitis-associated carcinogenesis. [Oncogene] Abstract

Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation
Scientists demonstrated that resistin-like molecule (RELM)-β and goblet cells play a role in recruiting CD4+ T cells to the colon to protect against an enteric pathogen, in part via the induction of increased intestinal epithelial cells proliferation. [PLoS Pathog] Full Article

Loss of ADAM17-Mediated TNFα Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition
Using total parenteral nutrition (TPN)-treated intestinal epithelial cell (IEC)-specific ADAM17-deficient mice, researchers demonstrated that a loss of soluble TNFα signaling from IECs attenuated TPN-induced mucosal atrophy. [Mol Cell Biol] Abstract

1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway
Investigators demonstrated that 1,25-dihydroxyvitamin D signaling preserved the mucosal barrier integrity by abrogating myosin light chain kinase -dependent tight junction dysregulation during colonic inflammation. [Inflamm Bowel Dis] Abstract

Iron-Induced Reactive Oxygen Species Mediate Transporter DMT1’s Endocytosis and Iron Uptake in Intestinal Epithelial Cells
Using selective surface protein biotinylation of polarized Caco-2 cells, researchers determined the kinetics of dimetal transporter 1 (DMT1) internalization from the apical membrane after an iron challenge. [Am J Physiol Cell Physiol] Abstract

Submicron Complex Lipid Carriers for Curcumin Delivery to Intestinal Epithelial Cells: Effect of Different Emulsifiers on Bioaccessibility and Cell Uptake
Submicrometric lipid-based carriers were developed to encapsulate curcumin and deliver it to intestinal epithelial cells. Uptake studies in HT29 cell lines, simulating intestinal epithelial cells, showed that whey protein isolates (WPI) and WPI with modified starch carriers exhibited a lower relative uptake than polysorbate 20 (T20)-stabilized systems as a consequence of smaller size and higher cell adherence of T20 carriers to the cell membrane. [Int J Pharm] Abstract | Graphical Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Notch Signaling Regulates Gastric Antral LGR5 Stem Cell Function
Researchers report that Notch signaling is essential for homeostasis of LGR5+ antral stem cells. Pathway inhibition reduced proliferation of gastric stem and progenitor cells, while activation increased proliferation. [EMBO J] Abstract | Graphical Abstract

Novel Regenerative Peptide TP508 Mitigates Radiation-Induced Gastrointestinal Damage by Activating Stem Cells and Preserving Crypt Integrity
TP508 treatment after lethal radiation exposure prevented the disintegration of gastrointestinal crypts, stimulated the expression of adherens junction protein E-cadherin, activated crypt cell proliferation, and decreased apoptosis. [Lab Invest] Abstract

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REVIEWS
New Insights into Immune Mechanisms Underlying Autoimmune Diseases of the Gastrointestinal Tract
The authors review novel advances in the immunological bases of autoimmune gastrointestinal disorders, and also highlight immune mechanisms of progression from chronic inflammation to cancer and implications for new therapeutic targets. [Autoimmun Rev] Abstract

Targeting Wnt Signaling in Colorectal Cancer
The authors discuss the Wnt activating mechanisms in colorectal cancer and review the current advances and challenges in drug discovery. [Am J Physiol Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
 
INDUSTRY NEWS
TGA Approves First mAb Biosimilar
Hospira announced that Inflectra™, the first monoclonal antibody (mAb) biosimilar therapy, has been registered in Australia. Inflectra has been registered in Australia for the treatment of eight inflammatory conditions: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; adult and pediatric Crohn’s disease; refractory fistulizing Crohn’s disease; adult and pediatric ulcerative colitis; and plaque psoriasis. [Hospira] Press Release

$52 Million NIH Grant Advances Clinical and Translational Research at UC San Diego
The Clinical and Translational Research Institute at University of California, San Diego has received a five-year Clinical and Translational Science Award for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health (NIH). [UC San Diego Health] Press Release

Esperite Acquires Patent to Use MSC-Derived Exosomes for Broad Applications in Immunology
Esperite has acquired the full rights of a broad international patent enabling MSC-derived exosomes use in treatment of inflammatory and autoimmune diseases. Esperite is positioned nto spearhead advances in treatment for graft versus host disease after solid organ and cell transplantations, Crohn’s disease, arthritis, multiple sclerosis, cystic fibrosis, stroke, traumatic brain and spinal cord injury, newborn encephalopathy, and type 1 diabetes among others. [Esperite N.V.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Pathology 2015
December 1-3, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the intestinal cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral or PhD position – Intestinal Lipidomics (Max Planck Institute of Molecular Cell Biology and Genetics)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Senior Research Technician (Qu Biologics Inc.)

Genetic Counselor – Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Researcher – Immunology and Microbiology (New York University School of Medicine)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

Bioinformatician – Inflammatory Bowel and Immunobiology Research (Cedars Sinai Medical Center)


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