Volume 1.21 | Aug 14

Intestinal Cell News 1.21 August 14, 2015
Intestinal Cell News
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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
The authors investigated the effects of the inflammatory mediator prostaglandin E2 (PGE2) on colorectal cancer stem cells (CSCs) development and metastasis in mice and the correlation between levels of PGE2 and CSC markers in human colorectal cancer specimens. [Gastroenterology] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting PRPS1 and RPIA mRNAs in Human Colorectal Cancer Cells
Researchers identified microRNAs that alter metabolism of glucose in colorectal cancer cells and determined their effects on tumor development. [Gastroenterology] Abstract

Wnt Addiction of Genetically Defined Cancers Reversed by PORCN Inhibition
Scientists developed a novel potent, orally available PORCN inhibitor, ETC-1922159 (ETC-159) that blocked the secretion and activity of all Wnts. ETC-159 was remarkably effective in treating RSPO-translocation bearing colorectal cancer patient-derived xenografts. [Oncogene] Abstract

Dipotassium Glycyrrhizate via HMGB1 or AMPK Signaling Suppresses Oxidative Stress during Intestinal Inflammation
The potential role of dipotassium glycyrrhizate (DPG), a salt of glycyrrhizin, to reduce oxidative stress in intestinal inflammatory condition was investigated in vivo and the mechanism of action of DPG was studied in vitro. [Biochem Pharmacol] Abstract

Differential Effects of HNF4α Isoforms on Tumor Growth and TCF4/AP-1 Interactions in Human Colorectal Cancer Cells
Investigators generated Tet-On inducible human colon cancer cell lines that express either the P1- (HNF4α2) or the P2-driven (HNF4α8) isoform and analyzed them for tumor growth and global changes in gene expression. [Mol Cell Biol] Abstract | Full Article

SPINK1 Promotes Colorectal Cancer Progression by Downregulating Metallothioneins Expression
The authors demonstrated the functional significance of SPINK1 (serine peptidase inhibitor, Kazal type 1) in colorectal cancer progression and metastases. Stable knockdown of SPINK1 significantly decreased cell proliferation, invasion and soft agar colony formation in the colon adenocarcinoma WiDr cells. [Oncogenesis] Full Article

Protective Effect of Hydrogen Sulfide on TNF-α and IFN-γ-Induced Injury of Intestinal Epithelial Barrier Function in Caco-2 Monolayers
Researchers investigated the possible protective effect of hydrogen sulfide on TNF-α/IFN-γ induced barrier dysfunction in Caco-2 cell monolayers. [Inflamm Res] Abstract

Long Chain Poly-Unsaturated Fatty Acids Attenuate the IL-1β-Induced Pro-Inflammatory Response in Human Fetal Intestinal Epithelial Cells
Researchers investigated the anti-inflammatory effects of docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid in human fetal and adult intestinal epithelial cells in primary culture. [Pediatr Res] Abstract


Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation
Complementary transgenic approaches and an intestinal regeneration model demonstrated the in vivo importance of CIP2A and serine 62 phosphorylation for MYC activity upon DNA damage. However, targeting of CIP2A did not influence the normal function of intestinal crypt cells. [Cell Rep]
Full Article
| Graphical Abstract| Press Release

Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury
Researchers determined the effects of dietary pectin on ionizing radiation (IR)-induced intestinal stem cell deletion, crypt and overall survival following lethal total-body gamma-IR. [PLoS One] Abstract

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Understanding Inflammatory Bowel Disease via Immunogenetics
The authors review our growing understanding of the immunogenetics of inflammatory bowel disease, from the twin studies that first implicated a role for the genome in disease susceptibility to the latest genome-wide association studies that have identified hundreds of associated loci. [J Autoimmun] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Stemedica Awarded U.S. Patent for Transgenic Therapeutic Stem Cells
Stemedica Cell Technologies Inc. received United States Patent No. 9080184 entitled “Transgenic Therapeutic Stem Cells and Methods for Their Use and Manufacture.” [Stemedica Cell Technologies] Press Release

Merck and MD Anderson Announce Immuno-Oncology Research Collaboration in Solid Tumors
Merck and The University of Texas MD Anderson Cancer Center announced a strategic clinical research collaboration to evaluate Merck’s anti-PD-1 therapy, KEYTRUDA®, in combination with other treatments, such as chemotherapy, radiation therapy and/or novel anti-tumor medicines. [The University of Texas MD Anderson Cancer Center] Abstract

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cells: From Basic Biology to Disease Therapy
October 19-22, 2015
Suzhou, China

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Senior Research Technician (Qu Biologics Inc.)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Genetic Counselor – Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Researcher – Immunology and Microbiology (New York University School of Medicine)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

Bioinformatician – Inflammatory Bowel and Immunobiology Research (Cedars Sinai Medical Center)

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