Volume 1.17 | Jul 17

Intestinal Cell News 1.17 July 17, 2015
Intestinal Cell News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
3-D Views Reveal Intricacies in Intestines That Could Lead to Discoveries for Inflammatory Bowel Disease
A technology whose roots date to the 1800s has the potential to offer a new advantage to modern-day medicine. Case Western Reserve scientists detail how stereomicroscopy can provide physicians with an invaluable diagnostic tool in assessing issues within the gastrointestinal tract. [Press release from Case Western Reserve University discussing online publication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

Wnt/β-Catenin Signaling Regulated SATB1 Promotes Colorectal Cancer Tumorigenesis and Progression
Using several colorectal cancer cell line models and the APC min mutant zebrafish in vivo model, researchers established that SATB1 is a novel target of Wnt/β-catenin signaling. [Oncogene] Abstract

miR-135b- and miR-146b-Dependent Silencing of Calcium-Sensing Receptor Expression in Colorectal Tumors
The authors demonstrated that miR-135b and miR-146b target the calcium-sensing receptor and reduced its expression in colorectal tumors, reducing the antiproliferative and prodifferentiating actions of calcium. [Int J Cancer] Abstract

Carnosic Acid Inhibits STAT3 Signaling and Induces Apoptosis through Generation of ROS in Human Colon Cancer HCT116 Cells
Investigators revealed that carnosic acid (CA) treatment significantly reduced the viability of human colon cancer HCT116, SW480, and HT-29 cells. Treatment with CA induced apoptosis, which was associated with the induction of p53 and Bax, inhibition of Mdm2, Bcl-2, and Bcl-xl expression, activation of caspase-9, and -3, and the cleavage of PARP in HCT116 cells. [Mol Carcinog] Abstract

Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis
To determine the role of Hdac1 and Hdac2 in the regulation of intestinal epithelial cell function and the establishment of the dual knockout phenotype, investigators generated villin-Cre murine models expressing one Hdac1 allele without Hdac2, or one Hdac2 allele without Hdac1. [J Cell Physiol] Abstract

Heterogeneity of Subordination of the IL-18/IFN-γ Axis to Caspase-1 among Patients with Crohn’s Disease
Scientists showed a correlation between secreted IFN-γ/IL-18 levels, and caspase-1 activation, with inflammation intensity of intestinal Crohn’s disease mucosa explants. [Lab Invest] Abstract

Comparing Two Intestinal Porcine Epithelial Cell Lines (IPECs): Morphological Differentiation, Function and Metabolism
IPEC-J2 was found to be a morphologically and functionally more differentiated cell line in comparison to IPEC-1. [PLoS One] Full Article

Derlin-1 Is Overexpressed in Human Colon Cancer and Promotes Cancer Cell Proliferation
Researchers examined Derlin-1 expression in colon cancer cell lines and human tissues and investigated its role in colon cancer. They found that Derlin-1 expression was increased significantly in colon cancer tissues and its overexpression correlated with the tumor differentiation, Dukes stage, invasion, lymph node metastasis, distant metastasis, and poor overall survival. [Mol Cell Biochem] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

SOX9 Maintains Reserve Stem Cells and Preserves Radio-Resistance in Mouse Small Intestine
Scientists performed single-cell analyses to characterize the expression of active and reserve intestinal stem cells markers in Lgr5high cells and Sox9high cells isolated from reporter mice by fluorescence-activated cell sorting. [Gastroenterology] Abstract

Watch Now: Webinar on Gastrointestinal Organoids by Dr. Meritxell Huch
 
REVIEWS
Reserve Stem Cells: Differentiated Cells Reprogram to Fuel Repair, Metaplasia, and Neoplasia in the Adult Gastrointestinal Tract
The authors review recent evidence showing that reprogramming fuels irreversible metaplastic and precancerous proliferation in the stomach and pancreas. Finally, they illustrate how we think reprogrammed differentiated cells are likely candidates as cells of origin for cancers of the intestine. [Sci Signal] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
 
INDUSTRY NEWS
Celgene to Acquire Receptos, Advancing Leadership in Immune-Inflammatory Diseases
Celgene Corporation and Receptos, Inc. announced the signing of a definitive agreement in which Celgene has agreed to acquire Receptos. The acquisition of Receptos builds upon Celgene’s growing expertise in inflammatory bowel disease. [Celgene Corporation] Press Release

apceth and University of Cologne to Join Forces on Combination Cellular Immunotherapies for Cancer
apceth announced a broad partnership with the Center for Molecular Medicine Cologne, University of Cologne, to combine technologies and expertise, on the development of immunotherapies for solid tumors and hematological malignancies. [apceth GmbH & Co. KG] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cold Spring Harbor Stem Cell Biology Meeting
October 7-11, 2015
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the intestinal cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Positions – Cancer Research (Rutgers University)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Immunology and Microbiology (New York University School of Medicine)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

Postdoctoral Position – Mechanics and Genetics of Embryonic and Tumoral Development (Institut Curie UMR 168)

Postdoctoral Fellow – Molecular Mechanisms of Inflammatory Bowel Disease (Emory University)

Bioinformatician – Inflammatory Bowel and Immunobiology Research (Cedars Sinai Medical Center)

Postdoctoral Researcher – Intestinal Diseases (Royal College of Surgeons in Ireland)

Postdoctoral Fellows – Colon Cancer Biology, Inflammatory Bowel Disease, and Intestinal Development (Rutgers University)


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