Volume 1.16 | Jul 10

Intestinal Cell News 1.16 July 10, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
New Wnt/β-Catenin Target Genes Promote Experimental Metastasis and Migration of Colorectal Cancer Cells through Different Signals
Three new genes from the colorectal cancer (CRC) metastasis signature, BOP1, CKS2 and NFIL3, were identified as direct transcription targets of β-catenin/TCF4. Overexpression and knocking down of these genes in CRC cells promoted and inhibited, respectively, experimental metastasis in mice, epithelial–mesenchymal transition and cell motility in culture. [Gut] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
INTESTINAL CANCERS & DISEASES

Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
In three out of 100 gastric cancer cases, researchers found recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor. Epithelial cell lines expressing CLDN18-ARHGAP26 displayed a dramatic loss of epithelial phenotype and long protrusions indicative of epithelial-mesenchymal transition. [Cell Rep] Full Article | Graphical Abstract

Oxytocin Evokes a Pulsatile PGE2 Release from Ileum Mucosa and Is Required for Repair of Intestinal Epithelium after Injury
Scientists identified a COX-2-derived pulsatile PGE2 release triggered by oxytocin (OT) in rat ileum mucosa. OT receptors are expressed in intestine crypt epithelial cells. Notably, OT evoked a dynamic change of [Ca2+]i in ileum crypts, which was responsible for this pulsatile release of PGE2. [Sci Rep] Full Article

miR-612 Negatively Regulates Colorectal Cancer Growth and Metastasis by Targeting AKT2
Investigators found that miR-612 expression was significantly lower in colorectal cancer (CRC) tissues or cells compared with peritumor tissues or normal cells, and lower in metastatic CRC specimens compared with non-metastatic specimens, whereas AKT2 exhibited opposite trend. [Cell Death Dis] Abstract

Positive Feedback of DDX6/C-Myc/PTB1 Regulated by miR-124 Contributes to Maintenance of the Warburg Effect in Colon Cancer Cells
Scientists showed that DDX6 was overexpressed in colorectal cancer specimens and regulated by microRNA (miR)-124 in colon cancer cells. [Biochim Biophys Acta] Abstract

Inhibition of Gastric Tumor Cell Growth Using Seed-Targeting LNA as Specific, Long-Lasting MicroRNA Inhibitors
Scientists assessed the efficiency and specificity of 8-mer locked nucleic acid (LNA)-modified oligonucleotides raised against the seeds of miR-372 and miR-373, two embryonic stem cell-specific microRNAs prominently expressed in the human gastric adenocarcinoma AGS cell line. [Mol Ther Nucleic Acids] Abstract

Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression
Researchers investigated the role of histone deacetylation as an important epigenetic mechanism that controls proliferation and differentiation of intestinal cells using the histone deacetylase inhibitor suberanilohydroxamic acid. [J Cell Biochem] Abstract

Cortactin Promotes Colon Cancer Progression by Regulating ERK Pathway
The authors investigated the role of cortactin in regulation of the proliferation of colon cancer derived cells both in vitro and in vivo. [Int J Oncol] Abstract

RPS24 Knockdown Inhibits Colorectal Cancer Cell Migration and Proliferation In Vitro
RPS24 gene expression was significantly inhibited in human colon cancer HCT116 and HT-29 cells using a lentivirus shRNA approach. Knockdown of RPS24 expression significantly inhibited cell proliferation, colony formation, cell migration and arrested cell in S phase. [Gene] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
To characterize cellular specialization and regional function in the Drosophila midgut, scientists generated RNA-sequencing transcriptomes of all five cell types isolated by FACS from each of the five regions, R1–R5. They identified transcriptional diversities among cell types and document regional differences within each cell type that define further specialization. [Cell Rep] Full Article | Graphical Abstract

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REVIEWS
Role of Epithelial Cells in the Pathogenesis and Treatment of Inflammatory Bowel Disease
The authors focus on the role of epithelial cells in the pathophysiology of inflammatory bowel diseases (IBD), and also give a perspective to the upcoming development of regenerative therapies that may become one of the therapeutic choices to achieve mucosal healing in refractory patients of IBD. [J Gastroenterol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
 
SCIENCE NEWS
Encorafenib-Based Regimens Show Promising Clinical Activity in BRAF-Mutant Colorectal Cancer Patients
Array BioPharma’s wholly-owned RAF inhibitor, encorafenib, was showcased during an oral presentation at the 2015 ESMO World Congress of Gastrointestinal Cancer. Data were shared from a Phase Ib trial and preliminary data from a Phase II expansion of that trial testing the combination of encorafenib and cetuximab, with or without the addition of alpelisib (BYL719) 1, an investigational PI3K inhibitor in patients with BRAF-mutant colorectal cancer. [Press release from Array Biopharma discussing research presented at the 2015 ESMO World Congress of Gastrointestinal Cancer, Barcelona] Press Release

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INDUSTRY NEWS
TxCell Announces FDA Acceptance of IND for Ovasave
TxCell SA personalized T cell immunotherapies using antigen specific regulatory T-cells for severe chronic inflammatory and autoimmune diseases, announced that the United States Food and Drug Administration (FDA) has accepted TxCell’s Investigational New Drug (IND) application for the company’s lead product, Ovasave®, currently in a Phase IIb clinical trial for the treatment of patients with refractory Crohn’s disease. [TxCell] Press Release

apceth and University of Cologne to Join Forces on Combination Cellular Immunotherapies for Cancer
apceth announced a broad partnership with the Center for Molecular Medicine Cologne, University of Cologne, to combine technologies and expertise, on the development of immunotherapies for solid tumors and hematological malignancies. [apceth®] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 6th International Conference on Stem Cells and Cancer (ICSCC-2015): Proliferation, Differentiation and Apoptosis
October 2-5, 2015
Pune, India

Visit our events page to see a complete list of events in the intestinal cell research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Immunology and Microbiology (New York University School of Medicine)

Research Associate – Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Position – Intestinal Immunology (Shanghai Institute of Immunology)

Postdoctoral Position – Mechanics and Genetics of Embryonic and Tumoral Development (Institut Curie UMR 168)

Postdoctoral Research Fellow – Dysfunctional Aging in Colorectal Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Molecular Mechanisms of Inflammatory Bowel Disease (Emory University)

Bioinformatician – Inflammatory Bowel and Immunobiology Research (Cedars Sinai Medical Center)

Postdoctoral Research Scientist – Colon Cancer (Cancer Research UK Beatson Institute in Glasgow)

Postdoctoral Researcher – Intestinal Diseases (Royal College of Surgeons in Ireland)

Postdoctoral Fellows – Colon Cancer Biology, Inflammatory Bowel Disease, and Intestinal Development (Rutgers University)


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