Stem vs Non-Stem Cell Origin of Colorectal Cancer|
The progression of colorectal cancer (CRC) from an early adenoma to carcinoma is accompanied by a well-characterised set of mutations including KRAS, SMAD4 and TP53. Using elegant genetic models the current paradigm is that the intestinal stem cell is the origin of CRC. However, human histology and recent studies, showing marked plasticity within the intestinal epithelium, may point to other cells of origin. [Br J Cancer] Abstract
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