Volume 1.12 | Jun 12

Intestinal Cell News 1.12 June 12, 2015
Intestinal Cell News
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Krt19+/Lgr5 Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine
Researchers demonstrated that the intermediate filament keratin-19 (Krt19) marks long-lived, radiation-resistant cells above the crypt base that generate Lgr5+ crypt-based columnar in the colon and intestine. In colorectal cancer models, Krt19+ cancer-initiating cells are also radioresistant, while Lgr5+ stem cells are radiosensitive. [Cell Stem Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Selenoprotein P Influences Colitis-Induced Tumorigenesis by Mediating Stemness and Oxidative Damage
Using intestinal organoid cultures, investigators found that, compared with those from wild-type animals, selenoprotein P-null cultures displayed increased stem cell characteristics that are coupled with increased ROS production, DNA damage, proliferation, decreased cell survival, and modulation of WNT signaling in response to H2O2-mediated oxidative stress. [J Clin Invest] Full Article

Upregulation of ATG3 Contributes to Autophagy Induced by the Detachment of Intestinal Epithelial Cells from the Extracellular Matrix, but Promotes Autophagy-Independent Apoptosis of the Attached Cells
In an effort to identify the mechanisms of detachment-induced autophagy and growth arrest of non-malignant cells, researchers found that detachment of these cells caused upregulation of ATG3 and that ATG3 upregulation contributed to autophagy and growth arrest of detached cells. [Autophagy] Abstract

Anti-G-CSF Treatment Induces Protective Tumor Immunity in Mouse Colon Cancer by Promoting Protective NK Cell, Macrophage and T Cell Responses
Investigators investigated the effects of therapeutic anti-granulocyte colony-stimulating factor (G-CSF) treatment on colorectal cancer growth and anti-tumor immune responses. [Oncotarget] Abstract

MiR-320e Is a Novel Prognostic Biomarker in Colorectal Cancer
Researchers conducted a systematic discovery and validation of microRNA biomarkers in two clinical trial cohorts of colorectal cancer patients. [Br J Cancer] Abstract

Activation of AMPK by Chitosan Oligosaccharide in Intestinal Epithelial Cells: Mechanism of Action and Potential Applications in Intestinal Disorders
The authors investigated the effect of chitosan oligosaccharide on AMP-activated protein kinase (AMPK) in intestinal epithelial cells and its potential applications in the intestinal diseases benefited from AMPK activation. [Biochem Pharmacol] Abstract

Polyelectrolyte Complex Containing Silver Nanoparticles with Antitumor Property on Caco-2 Colon Cancer Cells
Polyelectrolyte complex (beads) based on N,N,N-trimethyl chitosan/alginate and silver nanoparticles were loaded within beads. In vitro cytotoxicity assays using beads/silver nanoparticles indicated that this material significantly inhibited the growth of colon cancer cells [Int J Biol Macromol] Abstract

Mechanisms Underlying 3-Bromopyruvate-Induced Cell Death in Colon Cancer
The authors indicated that 3-bromopyruvate can suppress tumor growth and induce cell death by multiple mechanisms at the same time and concentration in different types of colon cancer cell by depleting cellular energy stores. [J Bioenerg Biomembr] Full Article

MicroRNA-429 Inhibits the Migration and Invasion of Colon Cancer Cells by Targeting PAK6/Cofilin Signaling
Scientists investigated the role of microRNA-429 (miR-429) in the regulation of migration and invasion of colon cancer cells using RT-qPCR and western blotting. They showed that the expression of miR-429 was reduced in colon cancer cell lines, when compared to a normal colon epithelial cell line. [Oncol Rep] Abstract


Ribosome Biogenesis Dysfunction Leads to p53-Mediated Apoptosis and Goblet Cell Differentiation of Mouse Intestinal Stem/Progenitor Cells
Scientists adopted a genetic approach to investigate the role of Notchless, an essential actor of ribosome biogenesis, in the adult mouse intestinal lineage. [Cell Death Dis] Abstract

Going to ISSCR 2015? We’ll see you there!
All for One and One for All: Regionalization of the Drosophila Intestine
The authors review recent studies deciphering the morphological and functional properties of the Drosophila adult midgut compartments. [Insect Biochem Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
NIH Awards $1.7 Million to Advance Exosome-Based Cancer Drug Technology Optioned by Exovita Biosciences
The National Institutes of Health (NIH) National Cancer Institute has awarded a five-year, $1.7 million grant to the University of New Mexico Health Sciences Center to advance the development of new, exosome-based technology that empowers the body’s own natural defenses to fight cancer. [Exovita Biosciences] Press Release

STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. will be presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [BIOTECanada] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2015 Midwest Conference on Cell Therapy & Regenerative Medicine
September 18-19, 2015
Kansas City, United States

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Research Scientist – Colon Cancer (Cancer Research UK Beatson Institute in Glasgow)

Research Associate, Intestinal Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Assistant (University of Cambridge)

Postdoctoral Researcher – Intestinal Diseases (Royal College of Surgeons in Ireland)

Senior Associate Scientist (Amgen)

Postdoctoral Fellows – Colon Cancer Biology, Inflammatory Bowel Disease, and Intestinal Development (Rutgers University)

Postdoctoral Fellowship – Immunology (University of Toronto)

Postdoctoral Position – Cellular and Mucosal Immunology (University of Pennsylvania)

Senior Associate Scientist – Inflammation Research (Amgen)

Postdoctoral Fellow – Colon Cancer Genetics, Epigenetics and Chemoprevention (Baylor Scott & White Health)

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