Volume 1.04 | Apr 17

Intestinal Cell News 1.04 April 17, 2015
Intestinal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Gut Instinct: How Intestinal Stem Cells Find Their Niche
Studying mice and chicks, whose intestinal formation is similar to humans, scientists found that the entire intestinal lining has stem cell properties at first. As the embryo develops, all but a few cells lose this potential. [Press release from Harvard Medical School discussing online publication in Cell]
Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function
The authors determined the role of epithelial butyrate metabolism in establishing the austere oxygenation profile of the distal gut. Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor coordinating barrier protection. [Cell Host Microbe]
Abstract | Graphical Abstract

miR-1269 Promotes Metastasis and Forms a Positive Feedback Loop with TGF-β
Investigators showed that miR-1269a promotes colorectal cancer metastasis and forms a positive feedback loop with transforming growth factor-β (TGF-β) signaling. [Nat Commun] Abstract

mTOR Inhibitors Induce Apoptosis in Colon Cancer Cells via CHOP-Dependent DR5 Induction on 4E-BP1 Dephosphorylation
Researchers showed that apoptosis plays a key role in everolimus and temsirolimus anti-tumor activities in colon cancer cells and xenografts through the DR5, FADD and caspase-8 axis, and is strongly enhanced by tumor necrosis factor-related apoptosis-inducing ligand and 5-fluorouracil. [Oncogene] Abstract

High Nitric Oxide Production, Secondary to Inducible-Nitric Oxide Synthase Expression, Is Essential for Regulation of the Tumor-Initiating Properties of Colon Cancer Stem Cells
Scientists showed an integral role for endogenous Nitric Oxide (NO) and inducible NO synthase activity in the biology of colon cancer stem cells (CSCs). Colon CSCs with high endogenous NO production displayed higher tumorigenic abilities than low endogenous NO fractions. [J Pathol] Abstract

Simulated Microgravity Disrupts Intestinal Homeostasis and Increases Colitis Susceptibility
Researchers investigated whether simulated microgravity influences the intestinal homeostasis and increases the susceptibility to colon inflammation. [FASEB J] Abstract

Sirt7 Promotes Gastric Cancer Growth and Inhibits Apoptosis by Epigenetically Inhibiting miR-34a
Scientists report that Sirtuin 7 (Sirt7), a nicotinamide adenine dinucleotide-dependent class III histone deacetylase, is over-expressed in human gastric cancer tissues. [Sci Rep] Full Article

PTEN Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-kB Pathway
Investigators demonstrated that tumor suppressor gene phosphatase and tensin homolog (PTEN) overexpression or knockdown in Lovo colon cancer cells decreased or increased paxillin expression, respectively. [J Biol Chem] Abstract | Full Article

Quercetin Represses Apolipoprotein B Expression by Inhibiting the Transcriptional Activity of C/EBPβ
To identify novel targets of quercetin in intestinal enterocytes, researchers performed mRNA profiling using human intestinal epithelial Caco-2 cells. [PLoS One] Full Article

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New Developments in Goblet Cell Mucus Secretion and Function
The mucus system differs substantially between the small and large intestine, although it is built around MUC2 mucin polymers in both cases. That goblet cells and the regulation of their secretion also differ between these two parts of the intestine is of fundamental importance for a better understanding of mucosal immunology. [Mucosal Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
Queen’s Researchers in £5 Million Program to Improve Bowel Cancer Survival
Researchers at Queen’s University Belfast have launched a revolutionary personalized treatment program to help improve bowel cancer survival rates. The £5 million initiative aims to fundamentally change how we treat bowel cancer patients by personalizing their treatments and ensuring that each patient gets access to the most effective therapies. [Queen’s University Belfast] Press Release

Soligenix Announces FDA Protocol Clearance of Pivotal Phase III Clinical Trial of SGX203 in Pediatric Crohn’s Disease
Soligenix, Inc. announced that an agreement has been reached with the US Food and Drug Administration (FDA) on the design of a Phase III clinical trial evaluating SGX203 in the treatment of pediatric Crohn’s disease. [Soligenix, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW SelectBio Stem Cells in Drug Discovery
June 2-3, 2015
Cambridge, United Kingdom

NEW The 11th Meeting on Cell Death
September 15-19, 2015
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the intestinal cell research community.
NEW Postdoctoral Fellow – Stem Cell Homeostasis in Gut Development and Disease (Sickkids Research Institute)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoc Physiology (Radboud University Nijmegen Medical Centre)

Assistant Investigator – Colon Cancer (Baylor Research Institute and Sammons Cancer Center)

Postdoctoral Research Fellow (Brigham and Women’s Hospital and the Dana-Farber Cancer Institute)

Senior Medical Advisor – Inflammation & Immunology (Celgene Corporation)

Research Fellows in Bioinformatics (University of Exeter)

Postdoctoral Fellow – Transcriptional Mechanisms of Stomach and Intestinal Stem Cells (Sickkids Research Institute)

Postdoctoral Position – Functional Role of Intestinal Macrophages (University of Massachusetts Medical School)

Postdoctoral Fellowship – New Therapies for Inflammatory Bowel Diseases (Cornell University)

Postdoctoral Positions – Microbiota in Cancer (Mount Sinai School of Medicine)

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