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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Palisade Bio Successfully Demonstrates Bioactivation of PALI-2108 in Ex-Vivo Study of Normal Healthy and Ulcerative Colitis Patients’ Stool
[Palisade Bio, Inc.] Palisade Bio, Inc. announced the completion of its analysis evaluating ex-vivo bioactivation of PALI-2108, an orally administered, locally acting colon-specific phosphodiesterase-4 inhibitor prodrug in development for patients affected by ulcerative colitis (UC). PALI-2108 exhibited efficient ex-vivo conversion into its active PDE4 inhibitor form in stool samples from both normal healthy volunteers and patients with UC.
New Research from Case Western Reserve University Aims to Block Tumor Growth in Colorectal Cancer Patients
[Case Western Reserve University] With a new five-year, $1.84 million grant from the National Cancer Institute, researchers from Case Western Reserve University hope to take a step closer to developing new treatment options for people with metastatic colorectal cancer by studying how a protein involved in colorectal cancer growth functions.
PREX2 Contributes to Radiation Resistance by Inhibiting Radiotherapy-Induced Tumor Immunogenicity via cGAS/STING/IFNs Pathway in Colorectal Cancer
[BMC Medicine] Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) emerged as a significantly upregulated gene in radioresistant colorectal cancer (CRC) cells. It augmented the radioresistant capacity of CRC cells and demonstrated potential as a marker for predicting radioresistance efficacy.
Inherited KDM6AA649T Facilitates Tumor-Immune Escape and Exacerbates Colorectal Signet-Ring Cell Carcinoma Outcomes
[Oncogene] Overexpression of lysine-specific demethylase 6A (KDM6)AA694T in colorectal signet-ring cell carcinoma (SRCC) cell line promoted cell proliferation, invasion and migration, which were further confirmed in vivo by constructing orthotopic tumor growth and lung metastasis models.
Recurrent RhoGAP Gene Fusion CLDN18-ARHGAP26 Promotes RHOA Activation and Focal Adhesion Kinase and YAP-TEAD Signaling in Diffuse Gastric Cancer
[Gut] Scientists developed a model to study the function of a fusion protein in the pathogenesis of diffuse gastric cancer (DGC). Using organoids generated from this model, they evaluated its oncogenic activity and the biochemical effects of the fusion protein on the RHOA pathway and its downstream cell biological effects in the pathogenesis of DGC.
USP12 Facilitates Gastric Cancer Progression via Stabilizing YAP
[Cell Death Discovery] The authors conducted a screening using a deubiquitinase small interfering RNA library, leading to the identification of USP12 as an important deubiquitinase in the context of Hippo/YAP axis and the progression of gastric cancer.
LPCAT2 Inhibits Colorectal Cancer Progression via the PRMT1/SLC7A11 Axis
[Oncogene] Scientists identified LPCAT2+ tumor cell populations with less malignancy than LPCAT2- tumor cells in human and mouse colorectal cancer (CRC) tissues using scRNA-seq. Combining in vitro and in vivo experiments, they found that LPCAT2 could inhibit the proliferation of CRC cells by inducing ferroptosis.
The Phosphatase Inhibitor LB-100 Creates Neoantigens in Colon Cancer Cells Through Perturbation of mRNA Splicing
[EMBO Reports] Scientists reported a sensitivity of the mRNA splicing machinery to phosphorylation changes in response to LB-100 in colorectal adenocarcinoma.
Colonic Crypt Stem Cell Functions Are Controlled by Tight Junction Protein Claudin-7 Through Notch/Hippo Signaling
[Annals Of The New York Academy Of Sciences] Scientists explored the role of claudin-7 in regulating colonic intestinal stem cell function. In 3D colonoid culture, claudin-7–deficient crypts were unable to survive and form spheroids. Inhibition of the Hippo pathway or activation of Notch signaling partially rescued the defective stem cell behavior.
The Role of Goblet Cells in Crohn’s Disease
[Cell And Bioscience] Scientists introduce the disease-related functions of goblet cells, their relationship with Crohn's disease, their possible mechanisms, and current Crohn's disease treatments targeting goblet cells.
DHX9 Maintains Epithelial Homeostasis by Restraining R-Loop-Mediated Genomic Instability in Intestinal Stem Cells
[Nature Communications] The authors observed reduced DEAH-box helicase 9 (DHX9) protein levels in IBD patients, and mice with conditional DHX9 depletion in the intestinal epithelium exhibited an increased susceptibility to experimental colitis.
Combination of Bazedoxifene with Chemotherapy and SMAC-Mimetics for the Treatment of Colorectal Cancer
[Cell Death & Disease] Investigators reported that bazedoxifene inhibited tumor growth via direct interaction with the gp130 receptor to suppress interleukin-6 (IL-6) and IL-11-mediated signal transducer and activator of transcription 3 signaling.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
